Detailed information of TA system TA156832

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-RelB
• Location: 1660645..1661158
• Replicon: chromosome
• Accession: NZ_CP053557
• Organism: Exiguobacterium sp. Helios

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HNY42_RS08605
• Protein ID: WP_131504042.1
• Coordinates: 1660892..1661158 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HNY42_RS08600
• Protein ID: WP_114595958.1
• Coordinates: 1660645..1660899 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HNY42_RS08570	1656062..1656562	-	501	WP_188004234.1	DinB family protein	-
HNY42_RS08575	1656676..1657911	-	1236	WP_188004235.1	MFS transporter	-
HNY42_RS08580	1658042..1658329	-	288	WP_188004236.1	hypothetical protein	-
HNY42_RS08585	1658495..1659040	+	546	WP_188004237.1	GNAT family N-acetyltransferase	-
HNY42_RS08590	1659104..1659334	-	231	WP_188004238.1	hypothetical protein	-
HNY42_RS08595	1659360..1660484	-	1125	WP_188004239.1	GGDEF domain-containing protein	-
HNY42_RS08600	1660645..1660899	+	255	WP_114595958.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HNY42_RS08605	1660892..1661158	+	267	WP_131504042.1	Txe/YoeB family addiction module toxin	Toxin
HNY42_RS08610	1661334..1661750	+	417	WP_188004240.1	NAD(+)--rifampin ADP-ribosyltransferase	-
HNY42_RS08615	1661865..1662563	+	699	WP_131504044.1	response regulator transcription factor	-
HNY42_RS08620	1662556..1663656	+	1101	WP_188004241.1	HAMP domain-containing histidine kinase	-
HNY42_RS08625	1663728..1664513	+	786	WP_188004242.1	M15 family metallopeptidase	-
HNY42_RS08630	1664587..1664904	+	318	WP_188005429.1	DUF402 domain-containing protein	-
HNY42_RS08635	1664924..1665712	-	789	WP_131504047.1	hypothetical protein	-
HNY42_RS08640	1665840..1666037	+	198	WP_131504048.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10633.12 Da
• Isoelectric Point: 9.8622

>T156832 WP_131504042.1 NZ_CP053557:1660892-1661158 [Exiguobacterium sp. Helios]
MSKVRLLFTDHGWEDYLYWKQEDRKKLKRINTLIEDVKRNGNLTGIGKPEALKGNLQGFYSRRIDSEHRLVYRSTSEQVE
ILQCRYHY

Nucleotide

• Length: 267 bp

>T156832 NZ_CP069071:3545368-3545712 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9956.29 Da
• Isoelectric Point: 4.6909

>AT156832 WP_114595958.1 NZ_CP053557:1660645-1660899 [Exiguobacterium sp. Helios]
MSIVTYSDARKNFKQILDQVHDDKEAVIISRKNNENAVLLSEEEYNRLMETIYLMRSPQNSVRLLESIEQLEQKKLTERT
LIDE

Nucleotide

• Length: 255 bp

>AT156832 NZ_CP069071:3545709-3546038 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA