Detailed information of TA system TA156830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2475967..2476638
• Replicon: chromosome
• Accession: NZ_CP053553
• Organism: Diaphorobacter sp. JS3050

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HND92_RS11850
• Protein ID: WP_172207168.1
• Coordinates: 2475967..2476407 (-)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: HND92_RS11855
• Protein ID: WP_172207170.1
• Coordinates: 2476408..2476638 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HND92_RS11830	2472827..2474052	+	1226	Protein_2332	IS110-like element ISAisp4 family transposase	-
HND92_RS11835	2474134..2474946	-	813	Protein_2333	SAM-dependent methyltransferase	-
HND92_RS11840	2475034..2475345	-	312	WP_172207164.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HND92_RS11845	2475342..2475791	-	450	WP_172207166.1	hypothetical protein	-
HND92_RS11850	2475967..2476407	-	441	WP_172207168.1	type II toxin-antitoxin system VapC family toxin	Toxin
HND92_RS11855	2476408..2476638	-	231	WP_172207170.1	antitoxin	Antitoxin
HND92_RS11860	2476943..2477137	+	195	WP_172207172.1	hypothetical protein	-
HND92_RS11865	2477061..2477963	-	903	WP_172207174.1	hypothetical protein	-
HND92_RS11870	2477960..2478280	-	321	WP_172207176.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 16071.40 Da
• Isoelectric Point: 8.5159

>T156830 WP_172207168.1 NZ_CP053553:c2476407-2475967 [Diaphorobacter sp. JS3050]
MAVRYLLDTNICIYIAKHNPPAVRARFEQLSADALAMSVITLGELQHGAEKSQARAKALAALQQLQSAIQVMPLTHAVGE
NYGQIRSSLERTGQPIGNNDLWIAAHARAEGWVLVTNNEREFCRVEGLAVENWVTPKQPAKTLSNK

Nucleotide

• Length: 441 bp

>T156830 NZ_CP069071:3171581-3171844 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8565.56 Da
• Isoelectric Point: 4.6895

>AT156830 WP_172207170.1 NZ_CP053553:c2476638-2476408 [Diaphorobacter sp. JS3050]
MTYARVFQSGNSQAVRLPKEFRFNAEQVEIFRQGNDIVLRERPTSAAAIFDALASLPADFMQAGRDDTAPQEREAF

Nucleotide

• Length: 231 bp

>AT156830 NZ_CP069071:3171296-3171577 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA