Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1574729..1575519 Replicon chromosome
Accession NZ_CP053553
Organism Diaphorobacter sp. JS3050

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HND92_RS07720 Protein ID WP_135149734.1
Coordinates 1575019..1575519 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HND92_RS07715 Protein ID WP_135149735.1
Coordinates 1574729..1575022 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HND92_RS07695 1571905..1572561 + 657 WP_011805663.1 OmpA family protein -
HND92_RS07700 1572641..1573354 + 714 WP_172206662.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
HND92_RS07705 1573351..1574028 + 678 WP_135149736.1 HAD-IA family hydrolase -
HND92_RS07715 1574729..1575022 + 294 WP_135149735.1 DUF1778 domain-containing protein Antitoxin
HND92_RS07720 1575019..1575519 + 501 WP_135149734.1 GNAT family N-acetyltransferase Toxin
HND92_RS07725 1575523..1575750 + 228 WP_135149733.1 hypothetical protein -
HND92_RS07730 1575756..1576067 - 312 Protein_1520 hypothetical protein -
HND92_RS07735 1576121..1577635 - 1515 WP_011804030.1 IS66 family transposase -
HND92_RS07740 1577716..1578027 - 312 WP_011804029.1 IS66 family insertion sequence element accessory protein TnpB -
HND92_RS07745 1578048..1578455 - 408 WP_041835871.1 transposase -
HND92_RS07750 1578508..1578681 - 174 WP_172204910.1 hypothetical protein -
HND92_RS07755 1578678..1580027 - 1350 WP_135149785.1 recombinase family protein -
HND92_RS07760 1580024..1580255 - 232 Protein_1526 DUF2924 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1577716..1578051 335


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-90)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18331.28 Da        Isoelectric Point: 10.0349

>T156829 WP_135149734.1 NZ_CP053553:1575019-1575519 [Diaphorobacter sp. JS3050]
VTLRAPEPLAAQHRLEGFDCGKPALNDWLLRHARQAQGSGSAKTFVVAVDDGRVAGYFSLTVGQVDTLEAPERIRKGMGQ
YPLPVVILARLAVSVVDQGRGIGFGLLQDAIRRTMLIAEQAGIRAMLTHPIDEEAARFYTRFGFIASPLREQQLLLLLKD
ARRWVL

Download         Length: 501 bp

>T156829 NZ_CP069071:c3130772-3130380 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10763.24 Da        Isoelectric Point: 5.8270

>AT156829 WP_135149735.1 NZ_CP053553:1574729-1575022 [Diaphorobacter sp. JS3050]
MTAVASSPSARSSRLGLRATPEQEVVLRRAAEVAHKSLTDFILDSACLAAEQTLLDQRLFMVSGSQYQALMDLLDRPEQT
NEGLRDLFARKAPWDTK

Download         Length: 294 bp

>AT156829 NZ_CP069071:c3130984-3130769 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References