Detailed information of TA system TA156828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 767614..768647
• Replicon: chromosome
• Accession: NZ_CP053553
• Organism: Diaphorobacter sp. JS3050

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: HND92_RS03775
• Protein ID: WP_172206005.1
• Coordinates: 768075..768647 (+)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: HND92_RS03770
• Protein ID: WP_172206003.1
• Coordinates: 767614..768078 (+)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HND92_RS03745	763159..763638	+	480	WP_172205993.1	hypothetical protein	-
HND92_RS03750	763631..765946	+	2316	WP_172205995.1	hypothetical protein	-
HND92_RS03755	766084..766557	+	474	WP_172205997.1	hypothetical protein	-
HND92_RS03760	766590..766916	+	327	WP_172205999.1	hypothetical protein	-
HND92_RS03765	766913..767503	+	591	WP_172206001.1	hypothetical protein	-
HND92_RS03770	767614..768078	+	465	WP_172206003.1	helix-turn-helix domain-containing protein	Antitoxin
HND92_RS03775	768075..768647	+	573	WP_172206005.1	PIN domain-containing protein	Toxin
HND92_RS03780	768811..769014	+	204	WP_172206007.1	hypothetical protein	-
HND92_RS03785	769001..769579	+	579	WP_172206009.1	hypothetical protein	-
HND92_RS03790	769774..770334	+	561	WP_172206011.1	hypothetical protein	-
HND92_RS03795	770331..771755	+	1425	WP_172206013.1	site-specific DNA-methyltransferase	-
HND92_RS03800	771736..773028	+	1293	WP_172206015.1	site-specific DNA-methyltransferase	-
HND92_RS03805	773025..773261	+	237	WP_172206017.1	hypothetical protein	-
HND92_RS03810	773237..773443	-	207	WP_172205868.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	683649..831535	147886

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• Helix-turn-helix domain, group 17 (83-130)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21550.69 Da
• Isoelectric Point: 5.5553

>T156828 WP_172206005.1 NZ_CP053553:768075-768647 [Diaphorobacter sp. JS3050]
MSSHFTVVYDACVLYPAPLRDLLMRLALTDRFRARWSNTIHDEWIRNLLKQRPELDPAALEKTRTLMNSNVRDSLVEGFE
HLIPAIELPDPDDRHVVAAAIHSGAETIVTFNLKDFPAGALDRYNLDAQHPDDFIVDLFDLHPASVLQALAEQRASLKKP
PKTADEFLDILLKQGLTQTVSILKDWKVAF

Nucleotide

• Length: 573 bp

>T156828 NZ_CP069071:c3128353-3127469 [Mycobacterium tuberculosis]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 17188.61 Da
• Isoelectric Point: 5.6254

>AT156828 WP_172206003.1 NZ_CP053553:767614-768078 [Diaphorobacter sp. JS3050]
MTTTQLPQTMPTAEEVALARESGRALSAYLQMRSETQQIEIFDDKGAAHPVRVPMSALRLLVDVLTEIGEGNAVSIIPVH
AELTTQEAADVLNVSRPHLVKLLESKEIPFHKTGTHRRVRYQDVIAYKERIDAERRKALDALAEQAQELGMGYE

Nucleotide

• Length: 465 bp

>AT156828 NZ_CP069071:c3129243-3128356 [Mycobacterium tuberculosis]
GTGGTGAGCCCAGCCGGCGCCGATCGGCGCATCCCCACGTGGGCGTCACGGGTGGTGTCCGGCCTCGCTCGCGATCGGCC
CGTAGTCGTCACGAAAGAGGATCTGACGCAACGGCTTACAGAGGCTGGGTGTGGACGCGACCCCGACTCCGCCATCCGCG
AACTGCGCCGCATTGGGTGGCTGGTCCAACTGCCGGTGAAAGGCACCTGGGCATTCATTCCCCCCGGCGAGGCCGCCATC
TCGGACCCGTATCTACCGCTGCGCTCGTGGCTGGCCCGTGACCAGAACGCGGGCTTCATGCTGGCCGGTGCATCCGCAGC
GTGGCACCTCGGATACCTGGACCGCCAACCCGACGGCCGCATCCCGATCTGGCTGCCGCCGGCCAAAAGGCTGCCCGACG
GCCTAGCATCGTATGTGTCCGTCGTGCGCATCCCCTGGAACGCGGCGGACACCGCACTGCTGGCTCCGCGTCCCGCGTTG
CTGGTCCGGCGGCGGCTCGACCTCGTCGCGTGGGCGACCGGGTTACCGGCGCTAGGACCAGAAGCATTACTTGTGCAAAT
CGCCACGCGCCCGGCCTCGTTCGGGCCGTGGGCCGACCTTGTCCCCCACCTTGACGACCTCGTCGCCGACTGCAGTGACG
AGCGCCTGGAGCGTCTACTGTCGGGCCGGCCGACATCGGCCTGGCAGCGTGCAAGCTACCTGCTGGACTCGGGCGGTGAA
CCGGCACGAGGCCAGGCGCTGCTGGCCAAGCGGCACACCGAAGTGATGCCGGTGACTCGATTCACCACCGCGCACAGCCG
CGACCGTGGCGAGAGTGTCTGGGCTCCCGAGTATCAGCTTGTCGACGAGCTCGTCGTACCGCTGCTGCGCGTGATCGGCA
AGGCGTGA