Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 767614..768647 Replicon chromosome
Accession NZ_CP053553
Organism Diaphorobacter sp. JS3050

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag HND92_RS03775 Protein ID WP_172206005.1
Coordinates 768075..768647 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag HND92_RS03770 Protein ID WP_172206003.1
Coordinates 767614..768078 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HND92_RS03745 763159..763638 + 480 WP_172205993.1 hypothetical protein -
HND92_RS03750 763631..765946 + 2316 WP_172205995.1 hypothetical protein -
HND92_RS03755 766084..766557 + 474 WP_172205997.1 hypothetical protein -
HND92_RS03760 766590..766916 + 327 WP_172205999.1 hypothetical protein -
HND92_RS03765 766913..767503 + 591 WP_172206001.1 hypothetical protein -
HND92_RS03770 767614..768078 + 465 WP_172206003.1 helix-turn-helix domain-containing protein Antitoxin
HND92_RS03775 768075..768647 + 573 WP_172206005.1 PIN domain-containing protein Toxin
HND92_RS03780 768811..769014 + 204 WP_172206007.1 hypothetical protein -
HND92_RS03785 769001..769579 + 579 WP_172206009.1 hypothetical protein -
HND92_RS03790 769774..770334 + 561 WP_172206011.1 hypothetical protein -
HND92_RS03795 770331..771755 + 1425 WP_172206013.1 site-specific DNA-methyltransferase -
HND92_RS03800 771736..773028 + 1293 WP_172206015.1 site-specific DNA-methyltransferase -
HND92_RS03805 773025..773261 + 237 WP_172206017.1 hypothetical protein -
HND92_RS03810 773237..773443 - 207 WP_172205868.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 683649..831535 147886


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

Helix-turn-helix domain, group 17

(83-130)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21550.69 Da        Isoelectric Point: 5.5553

>T156828 WP_172206005.1 NZ_CP053553:768075-768647 [Diaphorobacter sp. JS3050]
MSSHFTVVYDACVLYPAPLRDLLMRLALTDRFRARWSNTIHDEWIRNLLKQRPELDPAALEKTRTLMNSNVRDSLVEGFE
HLIPAIELPDPDDRHVVAAAIHSGAETIVTFNLKDFPAGALDRYNLDAQHPDDFIVDLFDLHPASVLQALAEQRASLKKP
PKTADEFLDILLKQGLTQTVSILKDWKVAF

Download         Length: 573 bp

>T156828 NZ_CP069071:c3128353-3127469 [Mycobacterium tuberculosis]
GTGGCCGGTCTGACCCGTGCGCTCGTTGCGCGTCACGCTCTTGGTCGGGCCGAGGCATACGACGCCGCTCTGCTCGACGT
CGCCCAGGACCACCTGCTGTACCTGCTGTCGCAGACCGTCCAGTTCGGCGATAACCGCCTGGTGTTCAAAGGCGGTACCA
GCTTACGGAAGTGCCGGCTGGGCAACGTCGGGCGGTTCTCCACTGATCTGGACTTCAGCGCGCCCGACGATGAGGTCGTG
CTGGAGGTGTGCGAGCTGATCGACGGCGCCCGTGTCGGCGGCTTCGAATTCGGCGTGCAGAGCACACGAGGCGACGGCCG
GCATTGGCAGTTGCGGGTGCGGCACACGGAATTGGGCGAGCCCCGGATCGTCGCCAGCGTCGAGTTCGCACGGCGGCCGT
TGGCTTTGCCGTCTGAGCTGCTCGCATTCATCCAGTTGCCGATCCATAAGGCTTACGGTTTTGGGCTGCCGACACTGCCG
GTCGTGGCAGAAGCGGAAGCCTGCGCAGAGAAACTCGCGCGGTACCGCCGCGTTGCGCTGGCACGGGACCTGTACGACCT
GAACCACTTCGCCTCGCGAACGATTGACGAACCGCTCGTGCGGCGGCTGTGGGTGCTCAAGGTGTGGGGTGATGTCGTCG
ATGACCGGCGCGGCACCCGGCCACTACGCGTCGAAGACGTCCTCGCCGCCCGCAGCGAGCACGACTTCCAGCCCGACTCG
ATCGGCGTGCTGACCCGTCCTGTCGCTATGGCTGCCTGGGAAGCTCGCGTTCGGAAGCGATTTGCGTTCCTCACTGACCT
CGACGCCGACGAGCAGCGGTGGGCCGCCTGCGACGAACGGCACCGCCGCGAAGTGGAGAACGCGCTGGCGGTGCTGCGGT
CCTGA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17188.61 Da        Isoelectric Point: 5.6254

>AT156828 WP_172206003.1 NZ_CP053553:767614-768078 [Diaphorobacter sp. JS3050]
MTTTQLPQTMPTAEEVALARESGRALSAYLQMRSETQQIEIFDDKGAAHPVRVPMSALRLLVDVLTEIGEGNAVSIIPVH
AELTTQEAADVLNVSRPHLVKLLESKEIPFHKTGTHRRVRYQDVIAYKERIDAERRKALDALAEQAQELGMGYE

Download         Length: 465 bp

>AT156828 NZ_CP069071:c3129243-3128356 [Mycobacterium tuberculosis]
GTGGTGAGCCCAGCCGGCGCCGATCGGCGCATCCCCACGTGGGCGTCACGGGTGGTGTCCGGCCTCGCTCGCGATCGGCC
CGTAGTCGTCACGAAAGAGGATCTGACGCAACGGCTTACAGAGGCTGGGTGTGGACGCGACCCCGACTCCGCCATCCGCG
AACTGCGCCGCATTGGGTGGCTGGTCCAACTGCCGGTGAAAGGCACCTGGGCATTCATTCCCCCCGGCGAGGCCGCCATC
TCGGACCCGTATCTACCGCTGCGCTCGTGGCTGGCCCGTGACCAGAACGCGGGCTTCATGCTGGCCGGTGCATCCGCAGC
GTGGCACCTCGGATACCTGGACCGCCAACCCGACGGCCGCATCCCGATCTGGCTGCCGCCGGCCAAAAGGCTGCCCGACG
GCCTAGCATCGTATGTGTCCGTCGTGCGCATCCCCTGGAACGCGGCGGACACCGCACTGCTGGCTCCGCGTCCCGCGTTG
CTGGTCCGGCGGCGGCTCGACCTCGTCGCGTGGGCGACCGGGTTACCGGCGCTAGGACCAGAAGCATTACTTGTGCAAAT
CGCCACGCGCCCGGCCTCGTTCGGGCCGTGGGCCGACCTTGTCCCCCACCTTGACGACCTCGTCGCCGACTGCAGTGACG
AGCGCCTGGAGCGTCTACTGTCGGGCCGGCCGACATCGGCCTGGCAGCGTGCAAGCTACCTGCTGGACTCGGGCGGTGAA
CCGGCACGAGGCCAGGCGCTGCTGGCCAAGCGGCACACCGAAGTGATGCCGGTGACTCGATTCACCACCGCGCACAGCCG
CGACCGTGGCGAGAGTGTCTGGGCTCCCGAGTATCAGCTTGTCGACGAGCTCGTCGTACCGCTGCTGCGCGTGATCGGCA
AGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References