Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 4456589..4457112 Replicon chromosome
Accession NZ_CP053544
Organism Paenarthrobacter sp. YJN-5

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HMI59_RS20690 Protein ID WP_193592381.1
Coordinates 4456589..4456909 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HMI59_RS20695 Protein ID WP_193592382.1
Coordinates 4456906..4457112 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMI59_RS20660 4452251..4452856 - 606 WP_193592377.1 malonic semialdehyde reductase -
HMI59_RS20665 4453114..4454469 + 1356 WP_193592378.1 NCS2 family nucleobase:cation symporter -
HMI59_RS20670 4454521..4454742 - 222 WP_021473232.1 helix-turn-helix transcriptional regulator -
HMI59_RS20675 4454742..4455233 - 492 WP_193592379.1 DUF2975 domain-containing protein -
HMI59_RS20680 4455459..4456025 + 567 WP_021473230.1 type 1 glutamine amidotransferase -
HMI59_RS20685 4456220..4456546 + 327 WP_193592380.1 hypothetical protein -
HMI59_RS20690 4456589..4456909 - 321 WP_193592381.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HMI59_RS20695 4456906..4457112 - 207 WP_193592382.1 antitoxin MazE family protein Antitoxin
HMI59_RS20700 4457209..4457760 + 552 WP_193593847.1 dihydrofolate reductase family protein -
HMI59_RS20705 4457867..4458166 - 300 WP_193592383.1 hypothetical protein -
HMI59_RS20710 4458929..4459672 + 744 WP_193592384.1 MBL fold metallo-hydrolase -
HMI59_RS20715 4459712..4459948 + 237 WP_069696621.1 DUF2630 family protein -
HMI59_RS20720 4459952..4461094 - 1143 WP_193592385.1 glycerate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-102)

Antitoxin

Antitoxin MazE-like

(4-67)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11583.59 Da        Isoelectric Point: 8.9971

>T156827 WP_193592381.1 NZ_CP053544:c4456909-4456589 [Paenarthrobacter sp. YJN-5]
VRGDIWTVAGGVFASKPRPALVIQDDRFDANDSLTVLPLTSTLVDIPLLRIPVQPSELSGLVRESHIMIDKLTTVRRASV
QTRVGRLAPVQMVEVERALLVFLGIA

Download         Length: 321 bp

>T156827 NZ_CP069071:c3103205-3102849 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7871.61 Da        Isoelectric Point: 5.5959

>AT156827 WP_193592382.1 NZ_CP053544:c4457112-4456906 [Paenarthrobacter sp. YJN-5]
MSVRERVSEHRRRMREAGFRSIQVWVPDTRAKNFAAEAHRQSAMAADAATHSDDQEWIEAVSVSWDDE

Download         Length: 207 bp

>AT156827 NZ_CP069071:c3103419-3103189 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References