Detailed information of TA system TA156825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 493003..494516
• Replicon: chromosome
• Accession: NZ_CP053544
• Organism: Paenarthrobacter sp. YJN-5

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: HMI59_RS02315
• Protein ID: WP_193592672.1
• Coordinates: 493003..494298 (-)
• Length: 432 a.a.

Antitoxin (Protein)

• Gene name: HipB2
• Uniprot ID: -
• Locus tag: HMI59_RS02320
• Protein ID: WP_021473955.1
• Coordinates: 494292..494516 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMI59_RS02295	488813..490228	-	1416	WP_021473950.1	aspartate ammonia-lyase	-
HMI59_RS02300	490238..491230	-	993	WP_193592670.1	asparaginase	-
HMI59_RS02305	491227..491955	-	729	WP_193592671.1	FCD domain-containing protein	-
HMI59_RS02310	492034..492888	-	855	WP_193593642.1	GIY-YIG nuclease family protein	-
HMI59_RS02315	493003..494298	-	1296	WP_193592672.1	type II toxin-antitoxin system HipA family toxin	Toxin
HMI59_RS02320	494292..494516	-	225	WP_021473955.1	helix-turn-helix domain-containing protein	Antitoxin
HMI59_RS02325	494672..495766	-	1095	WP_193592673.1	thermonuclease family protein	-
HMI59_RS02330	495976..496590	+	615	WP_031217027.1	hypothetical protein	-
HMI59_RS02335	496624..497085	+	462	WP_166187528.1	DUF3817 domain-containing protein	-
HMI59_RS02340	497441..498160	-	720	WP_193592674.1	hypothetical protein	-
HMI59_RS02345	498403..498816	-	414	WP_193593643.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-59)

Sequences

Toxin

Protein

• Length: 432 a.a.
• Molecular weight: 46946.25 Da
• Isoelectric Point: 6.2364

>T156825 WP_193592672.1 NZ_CP053544:c494298-493003 [Paenarthrobacter sp. YJN-5]
MVSTRALDVFMDGTLCGRVEQSASGNLVFDYLPEYQARRDATPLSLSMPLAARSHKKRAVLPFLQGLLPDSEGALQTIAR
RFRVSPANPFAVLEHIGADVAGALQFLPPGAESSDGKFQRTSVTPVSDSEVAAMLDHVVTEYEDGTPYDDAAGRFSLAGA
HPKIALHQLPDGTWAVPADATPTTHILKPAAGSFSRLDVVEQLTMRAAAFLGLEVANSELKRIGGWDVFVTRRYDRHALD
GTWRRLHQEDFCQALSVSPAKKYQHRDGGPGAGDMASLVRSFPLEADRRAAGESLYRAFVFNTVAGCTDAHAKNYSLLLH
GEEVRFAPLYDLATYAPYWDGESSINLAMSVKGEYRLQRISKQMLVATGAQFGVPSDAAESVVVHYCEQMIDAFDAAKKE
LLRELGSLPDIAEEVTARVRLLPLVVTAARK

Nucleotide

• Length: 1296 bp

>T156825 NZ_CP069071:c3063268-3062852 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8486.59 Da
• Isoelectric Point: 5.1369

>AT156825 WP_021473955.1 NZ_CP053544:c494516-494292 [Paenarthrobacter sp. YJN-5]
MRTVREAGPLVRELREERGWSQAELARRANVSRTFLIDLESGKATVETSKFMDVFQALGFELAIRDSETGDVRW

Nucleotide

• Length: 225 bp

>AT156825 NZ_CP069071:c3063531-3063265 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA