Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1365209..1365701 Replicon chromosome
Accession NZ_CP053541
Organism Vibrio europaeus strain NPI-1

Toxin (Protein)


Gene name relE Uniprot ID A0A178JEV0
Locus tag HOO69_RS06185 Protein ID WP_069666344.1
Coordinates 1365447..1365701 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A178JDY4
Locus tag HOO69_RS06180 Protein ID WP_069544518.1
Coordinates 1365209..1365457 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HOO69_RS06150 1361721..1362254 - 534 WP_069666338.1 lipocalin family protein -
HOO69_RS06155 1362288..1362785 - 498 WP_171383809.1 GNAT family N-acetyltransferase -
HOO69_RS06160 1362854..1363282 - 429 WP_171801590.1 hypothetical protein -
HOO69_RS06165 1363425..1364042 - 618 WP_069666341.1 LysE family translocator -
HOO69_RS06170 1364190..1364525 - 336 WP_171801591.1 hypothetical protein -
HOO69_RS06175 1364814..1365125 - 312 WP_171801592.1 antibiotic biosynthesis monooxygenase -
HOO69_RS06180 1365209..1365457 + 249 WP_069544518.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HOO69_RS06185 1365447..1365701 + 255 WP_069666344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HOO69_RS06190 1365813..1366223 - 411 WP_171801593.1 hypothetical protein -
HOO69_RS06195 1366359..1366904 - 546 WP_171801594.1 GNAT family N-acetyltransferase -
HOO69_RS06200 1367022..1367387 - 366 WP_171801595.1 VOC family protein -
HOO69_RS06205 1367558..1367869 - 312 WP_171801596.1 hypothetical protein -
HOO69_RS06210 1367930..1368781 - 852 WP_171801597.1 IS3 family transposase -
HOO69_RS06215 1368865..1369086 - 222 Protein_1208 transposase -
HOO69_RS06220 1369286..1369666 - 381 WP_171801598.1 energy transducer TonB -
HOO69_RS06225 1370296..1370661 - 366 WP_171802383.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1362288..1395578 33290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-71)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9761.54 Da        Isoelectric Point: 10.3924

>T156823 WP_069666344.1 NZ_CP053541:1365447-1365701 [Vibrio europaeus]
MTYKLDFKKSALKEWKKLIERLGNPHVPASKLSGADNMYKIKLCQSGYRLVYKVQDDVIIVTVLAVGKRERSDVYRKAMK
RLDD

Download         Length: 255 bp

>T156823 NZ_CP069071:2924233-2924673 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9049.34 Da        Isoelectric Point: 3.9610

>AT156823 WP_069544518.1 NZ_CP053541:1365209-1365457 [Vibrio europaeus]
MTTRILADVAASITELKANPMKVAASAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT156823 NZ_CP069071:2923959-2924246 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A178JEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A178JDY4

References