Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1150948..1151504 Replicon chromosome
Accession NZ_CP053541
Organism Vibrio europaeus strain NPI-1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HOO69_RS05210 Protein ID WP_171801475.1
Coordinates 1150948..1151253 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HOO69_RS05215 Protein ID WP_171801476.1
Coordinates 1151262..1151504 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HOO69_RS05180 1146171..1146536 - 366 WP_069666187.1 CidA/LrgA family protein -
HOO69_RS05185 1146682..1148106 - 1425 WP_171801470.1 exodeoxyribonuclease I -
HOO69_RS05190 1148603..1148848 + 246 WP_171801471.1 hypothetical protein -
HOO69_RS05195 1148935..1149609 + 675 WP_171801472.1 hypothetical protein -
HOO69_RS05200 1149853..1150404 + 552 WP_171801473.1 VRR-NUC domain-containing protein -
HOO69_RS05205 1150526..1150894 + 369 WP_171801474.1 hypothetical protein -
HOO69_RS05210 1150948..1151253 - 306 WP_171801475.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HOO69_RS05215 1151262..1151504 - 243 WP_171801476.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HOO69_RS05220 1151641..1153014 - 1374 WP_171801477.1 L-cystine transporter -
HOO69_RS05225 1153204..1153920 - 717 WP_171801478.1 oxidoreductase -
HOO69_RS05230 1154410..1155021 + 612 WP_069666192.1 flavin reductase family protein -
HOO69_RS05235 1155031..1156062 + 1032 WP_171801479.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12023.89 Da        Isoelectric Point: 9.8439

>T156822 WP_171801475.1 NZ_CP053541:c1151253-1150948 [Vibrio europaeus]
MPQRHFKLSKLAQRHLIKVKEYTLDNYSELQWQRYKDTLLSGFQLLAENPDLGRDCSEIYPQGFYFHIGKHTAYFTKENG
FILIVAVLNQSLLPEKHLKRR

Download         Length: 306 bp

>T156822 NZ_CP069071:c2864013-2863618 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9026.28 Da        Isoelectric Point: 4.8604

>AT156822 WP_171801476.1 NZ_CP053541:c1151504-1151262 [Vibrio europaeus]
MNTLTANDAKRNFGELLLSAQREPVKISKNSKDAVIVMSIKDYEELESMKAEYLKHCFESAKKDLAEGNTIDGESFLKEL

Download         Length: 243 bp

>AT156822 NZ_CP069071:c2864255-2864010 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References