Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4255..4817 Replicon plasmid pTSUKu5_12_unt9
Accession NZ_CP053483
Organism Thiothrix sp. Ku-5

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HMY34_RS19865 Protein ID WP_202719284.1
Coordinates 4255..4557 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HMY34_RS19870 Protein ID WP_202719288.1
Coordinates 4545..4817 (-) Length 91 a.a.

Genomic Context

HMY34_RS19835HMY34_RS19840HMY34_RS19845HMY34_RS19850HMY34_RS19905HMY34_RS19855HMY34_RS19860HMY34_RS19865HMY34_RS19870HMY34_RS19875HMY34_RS19880HMY34_RS19885HMY34_RS19890HMY34_RS19895HMY34_RS19900
Location: 330..644 (315 bp)
Type: Others
Protein ID: WP_202719278.1
Location: 1025..1717 (693 bp)
Type: Others
Protein ID: WP_202719279.1
Location: 1792..2709 (918 bp)
Type: Others
Protein ID: WP_202719280.1
Location: 2706..3185 (480 bp)
Type: Others
Protein ID: WP_202719281.1
Location: 9039..9383 (345 bp)
Type: Others
Protein ID: WP_202719289.1
Location: 3206..3472 (267 bp)
Type: Others
Protein ID: WP_202719282.1
Location: 3523..4164 (642 bp)
Type: Others
Protein ID: WP_202719283.1
Location: 4255..4557 (303 bp)
Type: Toxin
Protein ID: WP_202719284.1
Location: 4545..4817 (273 bp)
Type: Antitoxin
Protein ID: WP_202719288.1
Location: 4943..5248 (306 bp)
Type: Others
Protein ID: WP_202719285.1
Location: 5465..5875 (411 bp)
Type: Others
Protein ID: WP_202719286.1
Location: 5921..6208 (288 bp)
Type: Others
Protein ID: WP_202719287.1
Location: 6461..6982 (522 bp)
Type: Others
Protein ID: WP_202719273.1
Location: 7418..7672 (255 bp)
Type: Others
Protein ID: WP_202719274.1
Location: 7669..8316 (648 bp)
Type: Others
Protein ID: WP_202719275.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HMY34_RS19835330..644+315WP_202719278.1hypothetical protein-
HMY34_RS198401025..1717+693WP_202719279.1hypothetical protein-
HMY34_RS198451792..2709+918WP_202719280.1hypothetical protein-
HMY34_RS198502706..3185+480WP_202719281.1L,D-transpeptidase family protein-
HMY34_RS198553206..3472-267WP_202719282.1ribbon-helix-helix domain-containing protein-
HMY34_RS198603523..4164-642WP_202719283.1AAA family ATPase-
HMY34_RS198654255..4557-303WP_202719284.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HMY34_RS198704545..4817-273WP_202719288.1CopG family ribbon-helix-helix proteinAntitoxin
HMY34_RS198754943..5248-306WP_202719285.1hypothetical protein-
HMY34_RS198805465..5875-411WP_202719286.1hypothetical protein-
HMY34_RS198855921..6208-288WP_202719287.1hypothetical protein-
HMY34_RS198906461..6982-522WP_202719273.1hypothetical protein-
HMY34_RS198957418..7672-255WP_202719274.1hypothetical protein-
HMY34_RS199007669..8316-648WP_202719275.1recombinase family protein-
HMY34_RS199059039..9383+345WP_202719289.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..1211812118


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11354.20 Da        Isoelectric Point: 9.5300

>T156820 WP_202719284.1 NZ_CP053483:c4557-4255 [Thiothrix sp. Ku-5]
MPSLIFSHTALLDLERLRAFLRAKNLPAARRAVVKIMRGLQALEQHPELGHTVEDRPEDYRELVIPFGKDGYIAAYRYAG
DALVVLGVRHQRELQPPTLP

Download         Length: 303 bp

>T156820 NZ_CP069071:2862045-2862458 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10848.12 Da        Isoelectric Point: 5.5623

>AT156820 WP_202719288.1 NZ_CP053483:c4817-4545 [Thiothrix sp. Ku-5]
MPTSIKLDMDTKTRLQRLATSRQRSTHWLMQEAIRQYLEREEQLAQFRDEMQTAWDDYQDTGLHVTGKEVFAWMETWFTD
SEAQTPKCHH

Download         Length: 273 bp

>AT156820 NZ_CP069071:2862497-2862754 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References