Detailed information of TA system TA156820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4255..4817
• Replicon: plasmid pTSUKu5_12_unt9
• Accession: NZ_CP053483
• Organism: Thiothrix sp. Ku-5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HMY34_RS19865
• Protein ID: WP_202719284.1
• Coordinates: 4255..4557 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HMY34_RS19870
• Protein ID: WP_202719288.1
• Coordinates: 4545..4817 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMY34_RS19835	330..644	+	315	WP_202719278.1	hypothetical protein	-
HMY34_RS19840	1025..1717	+	693	WP_202719279.1	hypothetical protein	-
HMY34_RS19845	1792..2709	+	918	WP_202719280.1	hypothetical protein	-
HMY34_RS19850	2706..3185	+	480	WP_202719281.1	L,D-transpeptidase family protein	-
HMY34_RS19855	3206..3472	-	267	WP_202719282.1	ribbon-helix-helix domain-containing protein	-
HMY34_RS19860	3523..4164	-	642	WP_202719283.1	AAA family ATPase	-
HMY34_RS19865	4255..4557	-	303	WP_202719284.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMY34_RS19870	4545..4817	-	273	WP_202719288.1	CopG family ribbon-helix-helix protein	Antitoxin
HMY34_RS19875	4943..5248	-	306	WP_202719285.1	hypothetical protein	-
HMY34_RS19880	5465..5875	-	411	WP_202719286.1	hypothetical protein	-
HMY34_RS19885	5921..6208	-	288	WP_202719287.1	hypothetical protein	-
HMY34_RS19890	6461..6982	-	522	WP_202719273.1	hypothetical protein	-
HMY34_RS19895	7418..7672	-	255	WP_202719274.1	hypothetical protein	-
HMY34_RS19900	7669..8316	-	648	WP_202719275.1	recombinase family protein	-
HMY34_RS19905	9039..9383	+	345	WP_202719289.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..12118	12118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-93)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11354.20 Da
• Isoelectric Point: 9.5300

>T156820 WP_202719284.1 NZ_CP053483:c4557-4255 [Thiothrix sp. Ku-5]
MPSLIFSHTALLDLERLRAFLRAKNLPAARRAVVKIMRGLQALEQHPELGHTVEDRPEDYRELVIPFGKDGYIAAYRYAG
DALVVLGVRHQRELQPPTLP

Nucleotide

• Length: 303 bp

>T156820 NZ_CP069071:2862045-2862458 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10848.12 Da
• Isoelectric Point: 5.5623

>AT156820 WP_202719288.1 NZ_CP053483:c4817-4545 [Thiothrix sp. Ku-5]
MPTSIKLDMDTKTRLQRLATSRQRSTHWLMQEAIRQYLEREEQLAQFRDEMQTAWDDYQDTGLHVTGKEVFAWMETWFTD
SEAQTPKCHH

Nucleotide

• Length: 273 bp

>AT156820 NZ_CP069071:2862497-2862754 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA