Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3166430..3167079 Replicon chromosome
Accession NZ_CP053482
Organism Thiothrix sp. Ku-5

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag HMY34_RS15650 Protein ID WP_202716376.1
Coordinates 3166430..3166849 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag HMY34_RS15655 Protein ID WP_202716377.1
Coordinates 3166846..3167079 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMY34_RS15635 3161942..3162691 + 750 WP_202716373.1 hypothetical protein -
HMY34_RS15640 3162688..3163596 - 909 WP_202716374.1 signal peptidase I -
HMY34_RS15645 3163758..3166433 + 2676 WP_202716375.1 CRISPR-associated helicase/endonuclease Cas3 -
HMY34_RS15650 3166430..3166849 - 420 WP_202716376.1 type II toxin-antitoxin system VapC family toxin Toxin
HMY34_RS15655 3166846..3167079 - 234 WP_202716377.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HMY34_RS15660 3167338..3168801 + 1464 WP_202716378.1 type I-E CRISPR-associated protein Cse1/CasA -
HMY34_RS15665 3168798..3169238 + 441 WP_202716379.1 type I-E CRISPR-associated protein Cse2/CasB -
HMY34_RS15670 3169244..3170524 + 1281 WP_202716380.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
HMY34_RS15675 3170521..3171180 + 660 WP_202716381.1 type I-E CRISPR-associated protein Cas5/CasD -
HMY34_RS15680 3171167..3171766 + 600 WP_202716382.1 type I-E CRISPR-associated protein Cas6/Cse3/CasE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15895.40 Da        Isoelectric Point: 7.1658

>T156819 WP_202716376.1 NZ_CP053482:c3166849-3166430 [Thiothrix sp. Ku-5]
MNARYMMDTDTCIYLKNRRPPEIAERFRILQRGEVVMSMITYGELYNGAMKSRESEAALKNLQLLSERLPIQPMSVEVAK
NYGIIRSTLEKQGNKIGGNDLWIAAHALTMNLIIITNNTGEFERVPGLQVENWLETPLH

Download         Length: 420 bp

>T156819 NZ_CP069071:c2848577-2848158 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.00 Da        Isoelectric Point: 4.3063

>AT156819 WP_202716377.1 NZ_CP053482:c3167079-3166846 [Thiothrix sp. Ku-5]
MAITRVFQSGNSQAVRIPREFQIDAAEVEIFRRGDELILRKKQDNLLDVLDIFAAMPADFMEDSRNDPPPQERNFDA

Download         Length: 234 bp

>AT156819 NZ_CP069071:c2848798-2848574 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References