Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TacT3-ataR/DUF1778(antitoxin)
Location 1710375..1711150 Replicon chromosome
Accession NZ_CP053482
Organism Thiothrix sp. Ku-5

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag HMY34_RS08395 Protein ID WP_202718797.1
Coordinates 1710659..1711150 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag HMY34_RS08390 Protein ID WP_202718796.1
Coordinates 1710375..1710653 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMY34_RS08370 1705808..1707949 + 2142 Protein_1644 YgiQ family radical SAM protein -
HMY34_RS08375 1708009..1708686 + 678 WP_202718793.1 HNH endonuclease -
HMY34_RS08380 1708683..1709693 - 1011 WP_202718794.1 DNA cytosine methyltransferase -
HMY34_RS08385 1709705..1710061 - 357 WP_202718795.1 MarR family transcriptional regulator -
HMY34_RS08390 1710375..1710653 + 279 WP_202718796.1 DUF1778 domain-containing protein Antitoxin
HMY34_RS08395 1710659..1711150 + 492 WP_202718797.1 GNAT family N-acetyltransferase Toxin
HMY34_RS08400 1711283..1711960 + 678 WP_202718798.1 HNH endonuclease -
HMY34_RS08405 1711957..1712967 - 1011 WP_202718799.1 DNA cytosine methyltransferase -
HMY34_RS08410 1713072..1713293 + 222 WP_202718800.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HMY34_RS08415 1713272..1713631 - 360 WP_202718801.1 DUF2007 domain-containing protein -
HMY34_RS08420 1713647..1714678 - 1032 WP_202719163.1 CDP-6-deoxy-delta-3,4-glucoseen reductase -
HMY34_RS08425 1714785..1715981 + 1197 WP_202718802.1 formate-dependent phosphoribosylglycinamide formyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18116.01 Da        Isoelectric Point: 9.0802

>T156817 WP_202718797.1 NZ_CP053482:1710659-1711150 [Thiothrix sp. Ku-5]
MQIIPFNPAIARDAFDCGESALNHYLQQLAGQHSRKNVSRTFVAIDNDTVTGFYSLSMAESQLEDLPAATRKKLPPQYPV
PVARLSRLAVDKTCQGQRMGELLLMNALARCARIAGEIGTVGIIVDAKHEQAQRFYLKYGFTPYTTKPLTLFIPMQTVMQ
SLP

Download         Length: 492 bp

>T156817 NZ_CP069071:c2398134-2397817 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10264.81 Da        Isoelectric Point: 7.2042

>AT156817 WP_202718796.1 NZ_CP053482:1710375-1710653 [Thiothrix sp. Ku-5]
MPSTAAKDDRISIRTPPELKRMLIAAAAVSNISMTDFLLNAARKAAETVLAESRQITLNQQEWDRFMDLLDNPPPPNAAL
RAAMQRHHTLLD

Download         Length: 279 bp

>AT156817 NZ_CP069071:c2398346-2398131 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References