Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) brnT-shpB/BrnT-BrnA
Location 1647229..1647808 Replicon chromosome
Accession NZ_CP053482
Organism Thiothrix sp. Ku-5

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag HMY34_RS08110 Protein ID WP_202718747.1
Coordinates 1647229..1647513 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag HMY34_RS08115 Protein ID WP_202719160.1
Coordinates 1647554..1647808 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMY34_RS08080 1642574..1642846 + 273 WP_202718742.1 hypothetical protein -
HMY34_RS08085 1642861..1643535 + 675 WP_202718743.1 PspA/IM30 family protein -
HMY34_RS08090 1643887..1644702 + 816 WP_202719159.1 polyphosphate kinase 2 -
HMY34_RS08095 1644706..1645434 - 729 WP_202718744.1 transglycosylase SLT domain-containing protein -
HMY34_RS08100 1645541..1645774 - 234 WP_202718745.1 hypothetical protein -
HMY34_RS08105 1645787..1646866 - 1080 WP_202718746.1 hypothetical protein -
HMY34_RS08110 1647229..1647513 + 285 WP_202718747.1 BrnT family toxin Toxin
HMY34_RS08115 1647554..1647808 + 255 WP_202719160.1 BrnA antitoxin family protein Antitoxin
HMY34_RS08120 1647908..1648783 + 876 WP_202718748.1 SPFH/Band 7/PHB domain protein -
HMY34_RS08125 1648783..1649226 + 444 WP_202718749.1 NfeD family protein -
HMY34_RS08130 1649223..1650425 - 1203 WP_202718750.1 alanine--glyoxylate aminotransferase family protein -
HMY34_RS08135 1651311..1651778 + 468 WP_202719161.1 toll/interleukin-1 receptor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-85)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-74)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11079.29 Da        Isoelectric Point: 4.8433

>T156816 WP_202718747.1 NZ_CP053482:1647229-1647513 [Thiothrix sp. Ku-5]
MQFEWDDAKDASNQRKHGINFDLASLVFFDPLRIERYDGREQYNEDRWITIGLVNPALLYVVYTLRGQDDEIIRLISARK
ANESETRAYHQANS

Download         Length: 285 bp

>T156816 NZ_CP069071:c2361335-2360901 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9255.62 Da        Isoelectric Point: 9.8346

>AT156816 WP_202719160.1 NZ_CP053482:1647554-1647808 [Thiothrix sp. Ku-5]
MLATLAAKPDAAIDYSDAPPAAPGAEWYRAALNPLYRPNKQTTTVRLDADILAWLKSKGSGYQTRLNAILRESMLQELKQ
QAPK

Download         Length: 255 bp

>AT156816 NZ_CP069071:c2361596-2361342 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References