Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 1018032..1018804 Replicon chromosome
Accession NZ_CP053482
Organism Thiothrix sp. Ku-5

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HMY34_RS04920 Protein ID WP_202718185.1
Coordinates 1018316..1018804 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag HMY34_RS04915 Protein ID WP_202718184.1
Coordinates 1018032..1018319 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMY34_RS04890 1013512..1013937 - 426 WP_202718179.1 hypothetical protein -
HMY34_RS04895 1013934..1014449 - 516 WP_202718180.1 HyaD/HybD family hydrogenase maturation endopeptidase -
HMY34_RS04900 1014572..1015843 - 1272 WP_202718181.1 AI-2E family transporter -
HMY34_RS04905 1015936..1016484 + 549 WP_202718182.1 peptide deformylase -
HMY34_RS04910 1016581..1017951 + 1371 WP_202718183.1 ATP-binding protein -
HMY34_RS04915 1018032..1018319 + 288 WP_202718184.1 DUF1778 domain-containing protein Antitoxin
HMY34_RS04920 1018316..1018804 + 489 WP_202718185.1 GNAT family N-acetyltransferase Toxin
HMY34_RS04925 1018829..1019878 + 1050 WP_202718186.1 magnesium/cobalt transporter CorA -
HMY34_RS04930 1019882..1020298 - 417 WP_202718187.1 DUF1311 domain-containing protein -
HMY34_RS04935 1020324..1020644 - 321 WP_202718188.1 hypothetical protein -
HMY34_RS04940 1020808..1021452 - 645 WP_202718189.1 SPOR domain-containing protein -
HMY34_RS04945 1021437..1022195 - 759 WP_202718190.1 type III pantothenate kinase -
HMY34_RS04950 1022198..1023004 - 807 WP_202718191.1 biotin--[acetyl-CoA-carboxylase] ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(24-146)

Antitoxin

Vibrio phage ICP1, Orf50

(14-89)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 18087.91 Da        Isoelectric Point: 7.3520

>T156815 WP_202718185.1 NZ_CP053482:1018316-1018804 [Thiothrix sp. Ku-5]
MSVIRPPEPLRAQHEVDNFNCGEEVLDEWLQRRALKNEALGASRTFVACVEQRVVGYYALAAGSVTHSMVSSKVRRNMPE
PIPAIVLARLAIDKDWQGRGLGYSLLQDALLRCHAAAGYIGARVLLVHALTDDAKRFYEHFGFRASPIDERMLMLLLNEI
AA

Download         Length: 489 bp

>T156815 NZ_CP069071:2317890-2318300 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10527.03 Da        Isoelectric Point: 10.1783

>AT156815 WP_202718184.1 NZ_CP053482:1018032-1018319 [Thiothrix sp. Ku-5]
MTVATLPDSKATPLNIRIRQEQRSLIERAAAALDKTVSDFVRDAALREATNALLDKTVFHLNADAWAKFNAALDTPPASN
PRLQDLMSRQPVWAK

Download         Length: 288 bp

>AT156815 NZ_CP069071:2317664-2317897 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References