Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 516259..516890 Replicon chromosome
Accession NZ_CP053482
Organism Thiothrix sp. Ku-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HMY34_RS02525 Protein ID WP_202717751.1
Coordinates 516489..516890 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HMY34_RS02520 Protein ID WP_202717750.1
Coordinates 516259..516489 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMY34_RS02500 511409..513304 + 1896 WP_202717746.1 DNA topoisomerase IV subunit B -
HMY34_RS02505 513301..513789 + 489 WP_202717747.1 MEKHLA domain-containing protein -
HMY34_RS02510 513833..515515 + 1683 WP_202717748.1 hypothetical protein -
HMY34_RS02515 515492..516022 - 531 WP_202717749.1 tRNA adenosine(34) deaminase TadA -
HMY34_RS02520 516259..516489 + 231 WP_202717750.1 antitoxin Antitoxin
HMY34_RS02525 516489..516890 + 402 WP_202717751.1 type II toxin-antitoxin system VapC family toxin Toxin
HMY34_RS02530 516825..518099 - 1275 WP_202717752.1 tRNA lysidine(34) synthetase TilS -
HMY34_RS02535 518089..519042 - 954 WP_202717753.1 acetyl-CoA carboxylase carboxyltransferase subunit alpha -
HMY34_RS02540 519114..519884 - 771 WP_202717754.1 ferredoxin--NADP reductase -
HMY34_RS02545 519847..521487 - 1641 WP_202717755.1 NAD(P)/FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15382.62 Da        Isoelectric Point: 7.3568

>T156814 WP_202717751.1 NZ_CP053482:516489-516890 [Thiothrix sp. Ku-5]
MKRYMLDTDTSSYIIKNRPEQVAKRFRTLKMEQICISIITYAELLYGVERSSSERVNRPIIENFVAHLDVLDWDKDAADH
YSRVRAQLERSGTPIGGMDMQIGSHALSQGIILVTNNTRHFERIIGLQLETWV

Download         Length: 402 bp

>T156814 NZ_CP069071:2250104-2250502 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8899.19 Da        Isoelectric Point: 10.6826

>AT156814 WP_202717750.1 NZ_CP053482:516259-516489 [Thiothrix sp. Ku-5]
MPQTARLFMSGRSQAVRLPKQFRFQGNEVFIRRVGDQIILSPKPASWDDFFNDTQRPTADFMAERVDLPPQERVLF

Download         Length: 231 bp

>AT156814 NZ_CP069071:2249876-2250103 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References