Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 516259..516890 | Replicon | chromosome |
| Accession | NZ_CP053482 | ||
| Organism | Thiothrix sp. Ku-5 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | HMY34_RS02525 | Protein ID | WP_202717751.1 |
| Coordinates | 516489..516890 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | HMY34_RS02520 | Protein ID | WP_202717750.1 |
| Coordinates | 516259..516489 (+) | Length | 77 a.a. |
Genomic Context
Location: 511409..513304 (1896 bp)
Type: Others
Protein ID: WP_202717746.1
Type: Others
Protein ID: WP_202717746.1
Location: 513301..513789 (489 bp)
Type: Others
Protein ID: WP_202717747.1
Type: Others
Protein ID: WP_202717747.1
Location: 513833..515515 (1683 bp)
Type: Others
Protein ID: WP_202717748.1
Type: Others
Protein ID: WP_202717748.1
Location: 516259..516489 (231 bp)
Type: Antitoxin
Protein ID: WP_202717750.1
Type: Antitoxin
Protein ID: WP_202717750.1
Location: 516489..516890 (402 bp)
Type: Toxin
Protein ID: WP_202717751.1
Type: Toxin
Protein ID: WP_202717751.1
Location: 515492..516022 (531 bp)
Type: Others
Protein ID: WP_202717749.1
Type: Others
Protein ID: WP_202717749.1
Location: 516825..518099 (1275 bp)
Type: Others
Protein ID: WP_202717752.1
Type: Others
Protein ID: WP_202717752.1
Location: 518089..519042 (954 bp)
Type: Others
Protein ID: WP_202717753.1
Type: Others
Protein ID: WP_202717753.1
Location: 519114..519884 (771 bp)
Type: Others
Protein ID: WP_202717754.1
Type: Others
Protein ID: WP_202717754.1
Location: 519847..521487 (1641 bp)
Type: Others
Protein ID: WP_202717755.1
Type: Others
Protein ID: WP_202717755.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HMY34_RS02500 | 511409..513304 | + | 1896 | WP_202717746.1 | DNA topoisomerase IV subunit B | - |
| HMY34_RS02505 | 513301..513789 | + | 489 | WP_202717747.1 | MEKHLA domain-containing protein | - |
| HMY34_RS02510 | 513833..515515 | + | 1683 | WP_202717748.1 | hypothetical protein | - |
| HMY34_RS02515 | 515492..516022 | - | 531 | WP_202717749.1 | tRNA adenosine(34) deaminase TadA | - |
| HMY34_RS02520 | 516259..516489 | + | 231 | WP_202717750.1 | antitoxin | Antitoxin |
| HMY34_RS02525 | 516489..516890 | + | 402 | WP_202717751.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| HMY34_RS02530 | 516825..518099 | - | 1275 | WP_202717752.1 | tRNA lysidine(34) synthetase TilS | - |
| HMY34_RS02535 | 518089..519042 | - | 954 | WP_202717753.1 | acetyl-CoA carboxylase carboxyltransferase subunit alpha | - |
| HMY34_RS02540 | 519114..519884 | - | 771 | WP_202717754.1 | ferredoxin--NADP reductase | - |
| HMY34_RS02545 | 519847..521487 | - | 1641 | WP_202717755.1 | NAD(P)/FAD-dependent oxidoreductase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 15382.62 Da Isoelectric Point: 7.3568
>T156814 WP_202717751.1 NZ_CP053482:516489-516890 [Thiothrix sp. Ku-5]
MKRYMLDTDTSSYIIKNRPEQVAKRFRTLKMEQICISIITYAELLYGVERSSSERVNRPIIENFVAHLDVLDWDKDAADH
YSRVRAQLERSGTPIGGMDMQIGSHALSQGIILVTNNTRHFERIIGLQLETWV
MKRYMLDTDTSSYIIKNRPEQVAKRFRTLKMEQICISIITYAELLYGVERSSSERVNRPIIENFVAHLDVLDWDKDAADH
YSRVRAQLERSGTPIGGMDMQIGSHALSQGIILVTNNTRHFERIIGLQLETWV
Download Length: 402 bp
>T156814 NZ_CP069071:2250104-2250502 [Mycobacterium tuberculosis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8899.19 Da Isoelectric Point: 10.6826
>AT156814 WP_202717750.1 NZ_CP053482:516259-516489 [Thiothrix sp. Ku-5]
MPQTARLFMSGRSQAVRLPKQFRFQGNEVFIRRVGDQIILSPKPASWDDFFNDTQRPTADFMAERVDLPPQERVLF
MPQTARLFMSGRSQAVRLPKQFRFQGNEVFIRRVGDQIILSPKPASWDDFFNDTQRPTADFMAERVDLPPQERVLF
Download Length: 231 bp
>AT156814 NZ_CP069071:2249876-2250103 [Mycobacterium tuberculosis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCAACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG