Detailed information of TA system TA156812

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 102598..103244
• Replicon: chromosome
• Accession: NZ_CP053482
• Organism: Thiothrix sp. Ku-5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HMY34_RS00455
• Protein ID: WP_202717212.1
• Coordinates: 102598..102990 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HMY34_RS00460
• Protein ID: WP_202717213.1
• Coordinates: 102984..103244 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMY34_RS00430	98034..99371	+	1338	WP_202717207.1	exodeoxyribonuclease VII large subunit	-
HMY34_RS00435	99355..100362	-	1008	WP_202717208.1	hypothetical protein	-
HMY34_RS00440	100359..100964	-	606	WP_202717209.1	DUF938 domain-containing protein	-
HMY34_RS00445	101016..101573	+	558	WP_202717210.1	thermonuclease family protein	-
HMY34_RS00450	101580..102611	-	1032	WP_202717211.1	EF-P beta-lysylation protein EpmB	-
HMY34_RS00455	102598..102990	-	393	WP_202717212.1	type II toxin-antitoxin system VapC family toxin	Toxin
HMY34_RS00460	102984..103244	-	261	WP_202717213.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HMY34_RS00465	103391..103960	+	570	WP_202717214.1	elongation factor P	-
HMY34_RS00470	103957..104877	+	921	WP_202717215.1	EF-P lysine aminoacylase GenX	-
HMY34_RS00475	104912..105241	+	330	WP_202717216.1	preprotein translocase subunit YajC	-
HMY34_RS00480	105298..107151	+	1854	WP_202717217.1	protein translocase subunit SecD	-
HMY34_RS00485	107163..108113	+	951	WP_202717218.1	protein translocase subunit SecF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-122)

Antitoxin

• Antitoxin VapB-like (1-81)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14342.45 Da
• Isoelectric Point: 4.6268

>T156812 WP_202717212.1 NZ_CP053482:c102990-102598 [Thiothrix sp. Ku-5]
VVIDTSAIIAILLGEPEAEALSKAILDDPKRLMSAFSLLECSIVIESRKGEAGGRELDLLLYRLQVEIVDMNEEQTQLAR
AGWRQFGKGRHRAALNIGDCCSYALAKYTGEPLLFKGDDFNHSDITYVAL

Nucleotide

• Length: 393 bp

>T156812 NZ_CP069071:c2225130-2224570 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9893.33 Da
• Isoelectric Point: 5.1297

>AT156812 WP_202717213.1 NZ_CP053482:c103244-102984 [Thiothrix sp. Ku-5]
MALSIRNERAEQLAREIAQLTGYNMTSAIIMALEEKLERLQRFRRVNGKLDEIMVISRRCSALPDLDTRSADDILGYDEH
GVNTLW

Nucleotide

• Length: 261 bp

>AT156812 NZ_CP069071:c2225468-2225127 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA