Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1240120..1240926 Replicon chromosome
Accession NZ_CP053477
Organism Staphylococcus warneri strain WB224

Toxin (Protein)


Gene name tsbT Uniprot ID A0A2V3ZCG8
Locus tag EYQ96_RS06625 Protein ID WP_023373065.1
Coordinates 1240747..1240926 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A2V3ZD14
Locus tag EYQ96_RS06620 Protein ID WP_023373067.1
Coordinates 1240120..1240719 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYQ96_RS06600 1235909..1237369 + 1461 WP_171484932.1 ABC transporter permease subunit -
EYQ96_RS06605 1237362..1238084 + 723 WP_023373073.1 amino acid ABC transporter ATP-binding protein -
EYQ96_RS06610 1238340..1239473 + 1134 WP_023373071.1 tRNA epoxyqueuosine(34) reductase QueG -
EYQ96_RS06615 1239470..1239940 + 471 WP_023373069.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EYQ96_RS06620 1240120..1240719 + 600 WP_023373067.1 glucosamine-6-phosphate isomerase Antitoxin
EYQ96_RS06625 1240747..1240926 + 180 WP_023373065.1 hypothetical protein Toxin
EYQ96_RS06630 1241070..1241462 + 393 WP_023373063.1 hypothetical protein -
EYQ96_RS06635 1241616..1243001 + 1386 WP_023373062.1 class II fumarate hydratase -
EYQ96_RS06640 1243060..1243890 - 831 WP_023373060.1 RluA family pseudouridine synthase -
EYQ96_RS06645 1244068..1245180 + 1113 WP_023373058.1 GAF domain-containing sensor histidine kinase -
EYQ96_RS06650 1245201..1245824 + 624 WP_023373056.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6875.19 Da        Isoelectric Point: 3.9291

>T156808 WP_023373065.1 NZ_CP053477:1240747-1240926 [Staphylococcus warneri]
MTQNKDSKTNHHEEENAMVTDLDDLKDLGKEMEQISEENDEEKLNQSHDSDVRSDLDQD

Download         Length: 180 bp

>T156808 NZ_CP069071:c2186803-2186474 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22624.58 Da        Isoelectric Point: 5.3571

>AT156808 WP_023373067.1 NZ_CP053477:1240120-1240719 [Staphylococcus warneri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVDLHAVDFSQINILDYDKNQSYYEALGV
PQSQIYSLSYNQDANDFISDKIKTKENKGKLVLQVVSIDENGHLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNFEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT156808 NZ_CP069071:c2187177-2186800 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3ZCG8

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3ZD14

References