156807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1085778..1086307 Replicon chromosome
Accession NZ_CP053477
Organism Staphylococcus warneri strain WB224

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag EYQ96_RS05740 Protein ID WP_002451625.1
Coordinates 1085945..1086307 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag EYQ96_RS05735 Protein ID WP_002451626.1
Coordinates 1085778..1085948 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYQ96_RS05710 1081603..1082076 + 474 WP_023373293.1 PH domain-containing protein -
EYQ96_RS05715 1082069..1083595 + 1527 WP_023373291.1 PH domain-containing protein -
EYQ96_RS05720 1083582..1084079 + 498 WP_041613624.1 PH domain-containing protein -
EYQ96_RS05725 1084112..1084486 + 375 WP_171484900.1 holo-ACP synthase -
EYQ96_RS05730 1084538..1085686 + 1149 WP_023373286.1 alanine racemase -
EYQ96_RS05735 1085778..1085948 + 171 WP_002451626.1 hypothetical protein Antitoxin
EYQ96_RS05740 1085945..1086307 + 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EYQ96_RS05745 1086633..1087634 + 1002 WP_023373284.1 PP2C family protein-serine/threonine phosphatase -
EYQ96_RS05750 1087729..1088055 + 327 WP_002466754.1 anti-sigma factor antagonist -
EYQ96_RS05755 1088057..1088536 + 480 WP_002466768.1 anti-sigma B factor RsbW -
EYQ96_RS05760 1088511..1089281 + 771 WP_002451621.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T156807 WP_002451625.1 NZ_CP053477:1085945-1086307 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

>T156807 NZ_CP069071:1961513-1961761 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT156807 WP_002451626.1 NZ_CP053477:1085778-1085948 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT156807 NZ_CP069071:1961301-1961513 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References