Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1074656..1075166 Replicon chromosome
Accession NZ_CP053477
Organism Staphylococcus warneri strain WB224

Toxin (Protein)


Gene name TsdT Uniprot ID A0A2V3Z9H5
Locus tag EYQ96_RS05680 Protein ID WP_023373301.1
Coordinates 1074960..1075166 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A364UNN3
Locus tag EYQ96_RS05675 Protein ID WP_002466760.1
Coordinates 1074656..1074949 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYQ96_RS05650 1069786..1070577 + 792 WP_023373308.1 hydroxyethylthiazole kinase -
EYQ96_RS05655 1070578..1071219 + 642 WP_023373306.1 thiamine phosphate synthase -
EYQ96_RS05660 1071308..1072177 + 870 WP_002466746.1 membrane protein insertase YidC -
EYQ96_RS05665 1072217..1072861 - 645 WP_171484898.1 HD domain-containing protein -
EYQ96_RS05670 1072983..1074467 - 1485 WP_023373303.1 cardiolipin synthase -
EYQ96_RS05675 1074656..1074949 + 294 WP_002466760.1 copper-sensing transcriptional repressor CsoR Antitoxin
EYQ96_RS05680 1074960..1075166 + 207 WP_023373301.1 heavy-metal-associated domain-containing protein Toxin
EYQ96_RS05685 1075305..1075442 + 138 WP_002466770.1 hypothetical protein -
EYQ96_RS05690 1075582..1076772 - 1191 WP_023373299.1 rod shape-determining protein RodA -
EYQ96_RS05695 1077129..1078199 + 1071 WP_023373297.1 D-alanine--D-alanine ligase -
EYQ96_RS05700 1078215..1079576 + 1362 WP_023373295.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7628.58 Da        Isoelectric Point: 4.0101

>T156806 WP_023373301.1 NZ_CP053477:1074960-1075166 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSDAIKNLLTEMIGVHQVEIDINTGNISIEFETPANLNSIEKEIYDAGFKVLY

Download         Length: 207 bp

>T156806 NZ_CP069071:c1940901-1940512 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11199.74 Da        Isoelectric Point: 6.3263

>AT156806 WP_002466760.1 NZ_CP053477:1074656-1074949 [Staphylococcus warneri]
VTEQDHAHHSEQIKVNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIADKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT156806 NZ_CP069071:c1941125-1940898 [Mycobacterium tuberculosis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3Z9H5

Antitoxin

Source ID Structure
AlphaFold DB A0A364UNN3

References