Detailed information of TA system TA156798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazE-MazF
• Location: 431313..431872
• Replicon: chromosome
• Accession: NZ_CP053435
• Organism: Spirosoma taeanense strain TS118

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HNV11_RS01920
• Protein ID: WP_171738055.1
• Coordinates: 431313..431555 (+)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HNV11_RS01925
• Protein ID: WP_171738056.1
• Coordinates: 431549..431872 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HNV11_RS01900	426572..428374	-	1803	WP_171742024.1	glycoside hydrolase family 2	-
HNV11_RS01905	428646..429995	-	1350	WP_171738052.1	PQQ-dependent sugar dehydrogenase	-
HNV11_RS01910	430204..430545	+	342	WP_171738053.1	tRNA-binding protein	-
HNV11_RS01915	430591..430992	-	402	WP_171738054.1	hypothetical protein	-
HNV11_RS01920	431313..431555	+	243	WP_171738055.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Toxin
HNV11_RS01925	431549..431872	+	324	WP_171738056.1	type II toxin-antitoxin system PemK/MazF family toxin	Antitoxin
HNV11_RS01930	431875..432420	+	546	WP_171738057.1	hypothetical protein	-
HNV11_RS01935	432432..435125	-	2694	WP_171738058.1	hypothetical protein	-
HNV11_RS01940	435378..436739	+	1362	WP_171738059.1	M20/M25/M40 family metallo-hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• SpoVT-AbrB domain (8-48)

Antitoxin

• mRNA interferase PemK-like (5-105)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9420.69 Da
• Isoelectric Point: 5.6994

>T156798 WP_171738055.1 NZ_CP053435:431313-431555 [Spirosoma taeanense]
MRLAVVSIGNSKGIRIPKAILDKYQIRDSVELELREDGLLLKPVRTPRDGWENSFRQMHENGDDRLPFPDEFTHEIWTSW

Nucleotide

• Length: 243 bp

>T156798 NZ_CP069071:c1232224-1231913 [Mycobacterium tuberculosis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACACCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11902.55 Da
• Isoelectric Point: 5.0626

>AT156798 WP_171738056.1 NZ_CP053435:431549-431872 [Spirosoma taeanense]
MVINQYDVALVSSEPTAGGDVRPPRPCVIISPNEMNRQVDTLVVAPMTVTSKSYPSRVPVRSNGHTGWVVLDQIRTVDRQ
QVSQVLGRLSQDETDEIKQVIKELFVD

Nucleotide

• Length: 324 bp

>AT156798 NZ_CP069071:c1232544-1232224 [Mycobacterium tuberculosis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A