Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3471070..3471719 Replicon chromosome
Accession NZ_CP053419
Organism Cellulosimicrobium sp. 72-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HKK73_RS15510 Protein ID WP_171468335.1
Coordinates 3471297..3471719 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HKK73_RS15505 Protein ID WP_031315781.1
Coordinates 3471070..3471300 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HKK73_RS15490 3468190..3468744 - 555 WP_021479810.1 hypoxanthine phosphoribosyltransferase -
HKK73_RS15495 3468750..3469850 - 1101 WP_171468334.1 tRNA lysidine(34) synthetase TilS -
HKK73_RS15500 3469854..3471068 - 1215 WP_171468799.1 zinc-dependent metalloprotease -
HKK73_RS15505 3471070..3471300 + 231 WP_031315781.1 antitoxin Antitoxin
HKK73_RS15510 3471297..3471719 + 423 WP_171468335.1 PIN domain-containing protein Toxin
HKK73_RS15515 3471754..3473166 - 1413 WP_051028618.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase -
HKK73_RS15520 3473427..3473930 + 504 WP_034655165.1 inorganic diphosphatase -
HKK73_RS15525 3474000..3475397 - 1398 WP_171468336.1 C40 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(6-42)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15031.07 Da        Isoelectric Point: 5.9842

>T156797 WP_171468335.1 NZ_CP053419:3471297-3471719 [Cellulosimicrobium sp. 72-3]
VSTLYLLDTNVLVALLRGHGAAARPRLREAEGRVAVSTVSEMELEYGVERSQDPARNRHAVDELLSLVDVLPFDSLAAMH
AGRVRAVLAARGTPVGPYDALLAGHARSLGLVLVTNNVREFSRVSGLEVEDWLADATHGP

Download         Length: 423 bp

>T156797 NZ_CP069071:1168990-1169871 [Mycobacterium tuberculosis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8430.42 Da        Isoelectric Point: 7.0138

>AT156797 WP_031315781.1 NZ_CP053419:3471070-3471300 [Cellulosimicrobium sp. 72-3]
VRTTVFRSNRTQAVRLPKAVALPDDVREVDVRAVGRSRVITPAGSGWDEWFEHGLRVGPGFLADRDQGTADEREAL

Download         Length: 231 bp

>AT156797 NZ_CP069071:1168370-1168993 [Mycobacterium tuberculosis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTATGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References