Detailed information of TA system TA156796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4051799..4052541
• Replicon: chromosome
• Accession: NZ_CP053417
• Organism: Salmonella bongori strain 92-0238

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: CBX32_RS18745
• Protein ID: WP_079772897.1
• Coordinates: 4052053..4052541 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: S5MPV7
• Locus tag: CBX32_RS18740
• Protein ID: WP_020844238.1
• Coordinates: 4051799..4052065 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBX32_RS18730	4047033..4049561	+	2529	WP_171923489.1	malto-oligosyltrehalose synthase	-
CBX32_RS18735	4049604..4051679	+	2076	WP_020844239.1	glycogen debranching protein GlgX	-
CBX32_RS18740	4051799..4052065	+	267	WP_020844238.1	DUF1778 domain-containing protein	Antitoxin
CBX32_RS18745	4052053..4052541	+	489	WP_079772897.1	GNAT family N-acetyltransferase	Toxin
CBX32_RS18750	4053125..4053514	+	390	WP_171923490.1	RidA family protein	-
CBX32_RS18755	4053582..4054661	-	1080	WP_171923491.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
CBX32_RS18760	4054838..4055326	-	489	WP_079772898.1	MarR family winged helix-turn-helix transcriptional regulator	-
CBX32_RS18765	4055371..4056879	+	1509	WP_171923492.1	FAD-dependent monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (32-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17779.59 Da
• Isoelectric Point: 9.5852

>T156796 WP_079772897.1 NZ_CP053417:4052053-4052541 [Salmonella bongori]
VGKVTAPAPLSTLHNLAEFCCGESLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEAMGSLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Nucleotide

• Length: 489 bp

>T156796 NZ_CP069071:1015077-1015511 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9999.47 Da
• Isoelectric Point: 4.7961

>AT156796 WP_020844238.1 NZ_CP053417:4051799-4052065 [Salmonella bongori]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Nucleotide

• Length: 267 bp

>AT156796 NZ_CP069071:1014892-1015071 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Antitoxin

• AlphaFold DB: S5MPV7