Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2603521..2604181 Replicon chromosome
Accession NZ_CP053417
Organism Salmonella bongori strain 92-0238

Toxin (Protein)


Gene name cptA Uniprot ID S5NC56
Locus tag CBX32_RS12000 Protein ID WP_000244759.1
Coordinates 2603768..2604181 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag CBX32_RS11995 Protein ID WP_000351186.1
Coordinates 2603521..2603787 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBX32_RS11975 2599518..2600951 - 1434 WP_079774384.1 6-phospho-beta-glucosidase -
CBX32_RS11980 2601109..2601420 + 312 WP_079773282.1 N(4)-acetylcytidine aminohydrolase -
CBX32_RS11985 2601584..2602243 + 660 WP_024143399.1 hemolysin III family protein -
CBX32_RS11990 2602294..2603274 - 981 WP_000896119.1 tRNA-modifying protein YgfZ -
CBX32_RS11995 2603521..2603787 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
CBX32_RS12000 2603768..2604181 + 414 WP_000244759.1 protein YgfX Toxin
CBX32_RS12005 2604233..2604754 - 522 WP_171922994.1 flavodoxin FldB -
CBX32_RS12010 2604867..2605763 + 897 WP_000806655.1 site-specific tyrosine recombinase XerD -
CBX32_RS12015 2605787..2606500 + 714 WP_171922995.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CBX32_RS12020 2606506..2608239 + 1734 WP_038392510.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16190.13 Da        Isoelectric Point: 9.4274

>T156787 WP_000244759.1 NZ_CP053417:2603768-2604181 [Salmonella bongori]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGE
DWVLLRPPWLLNSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRVMLQQPLSGQH

Download         Length: 414 bp

>T156787 NZ_CP069071:703106-703507 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT156787 WP_000351186.1 NZ_CP053417:2603521-2603787 [Salmonella bongori]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT156787 NZ_CP069071:702864-703109 [Mycobacterium tuberculosis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NC56

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References