Detailed information of TA system TA156775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4025484..4026226
• Replicon: chromosome
• Accession: NZ_CP053416
• Organism: Salmonella bongori strain 85-0051

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: CBY01_RS18735
• Protein ID: WP_079773965.1
• Coordinates: 4025484..4025972 (-)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: S5MPV7
• Locus tag: CBY01_RS18740
• Protein ID: WP_020844238.1
• Coordinates: 4025960..4026226 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBY01_RS18715	4021160..4022668	-	1509	WP_038391421.1	FAD-dependent oxidoreductase	-
CBY01_RS18720	4022713..4023201	+	489	WP_038391423.1	MarR family winged helix-turn-helix transcriptional regulator	-
CBY01_RS18725	4023378..4024445	+	1068	WP_079794120.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
CBY01_RS18730	4024526..4024915	-	390	WP_015702869.1	RidA family protein	-
CBY01_RS18735	4025484..4025972	-	489	WP_079773965.1	GNAT family N-acetyltransferase	Toxin
CBY01_RS18740	4025960..4026226	-	267	WP_020844238.1	DUF1778 domain-containing protein	Antitoxin
CBY01_RS18745	4026346..4028421	-	2076	WP_079794100.1	glycogen debranching protein GlgX	-
CBY01_RS18750	4028464..4030992	-	2529	WP_079794099.1	malto-oligosyltrehalose synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (33-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17749.56 Da
• Isoelectric Point: 9.5852

>T156775 WP_079773965.1 NZ_CP053416:c4025972-4025484 [Salmonella bongori]
VGKVTAPAPLSTLHNLAEFCCGEGLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEAMGSLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Nucleotide

• Length: 489 bp

>T156775 NZ_CP069070:3785053-3785310 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9999.47 Da
• Isoelectric Point: 4.7961

>AT156775 WP_020844238.1 NZ_CP053416:c4026226-4025960 [Salmonella bongori]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Nucleotide

• Length: 267 bp

>AT156775 NZ_CP069070:3784781-3785056 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Structures

Antitoxin

• AlphaFold DB: S5MPV7