Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3059593..3060213 Replicon chromosome
Accession NZ_CP053416
Organism Salmonella bongori strain 85-0051

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CBY01_RS14200 Protein ID WP_001280991.1
Coordinates 3059593..3059811 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CBY01_RS14205 Protein ID WP_000344807.1
Coordinates 3059839..3060213 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CBY01_RS14160 3054832..3055401 + 570 WP_000779806.1 YbaY family lipoprotein -
CBY01_RS14165 3055434..3055823 - 390 WP_079794202.1 MGMT family protein -
CBY01_RS14175 3056062..3057612 - 1551 WP_020842828.1 EAL domain-containing protein -
CBY01_RS14180 3057816..3058076 + 261 WP_000801419.1 type B 50S ribosomal protein L31 -
CBY01_RS14185 3058082..3058222 + 141 WP_079794201.1 type B 50S ribosomal protein L36 -
CBY01_RS14190 3058275..3058745 - 471 WP_079772190.1 YlaC family protein -
CBY01_RS14195 3058863..3059414 - 552 WP_079794200.1 maltose O-acetyltransferase -
CBY01_RS14200 3059593..3059811 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
CBY01_RS14205 3059839..3060213 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CBY01_RS14210 3060709..3063858 - 3150 WP_001132513.1 multidrug efflux RND transporter permease subunit -
CBY01_RS14215 3063881..3065074 - 1194 WP_020842830.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T156774 WP_001280991.1 NZ_CP053416:c3059811-3059593 [Salmonella bongori]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T156774 NZ_CP069070:c3719631-3719203 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT156774 WP_000344807.1 NZ_CP053416:c3060213-3059839 [Salmonella bongori]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT156774 NZ_CP069070:c3719877-3719635 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References