Detailed information of TA system TA156773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 2447462..2448105
• Replicon: chromosome
• Accession: NZ_CP053416
• Organism: Salmonella bongori strain 85-0051

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: CBY01_RS11430
• Protein ID: WP_079793518.1
• Coordinates: 2447462..2447878 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: B5F3H9
• Locus tag: CBY01_RS11435
• Protein ID: WP_001261294.1
• Coordinates: 2447875..2448105 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CBY01_RS11410	2442499..2443632	+	1134	WP_079793516.1	amidohydrolase/deacetylase family metallohydrolase	-
CBY01_RS11415	2443616..2444734	+	1119	WP_079793517.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
CBY01_RS11420	2444731..2445471	+	741	WP_079772538.1	KDGP aldolase family protein	-
CBY01_RS11425	2445488..2447401	+	1914	WP_141024896.1	BglG family transcription antiterminator	-
CBY01_RS11430	2447462..2447878	-	417	WP_079793518.1	type II toxin-antitoxin system VapC family toxin	Toxin
CBY01_RS11435	2447875..2448105	-	231	WP_001261294.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CBY01_RS11440	2448273..2448737	-	465	WP_038393600.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
CBY01_RS11445	2448954..2451092	-	2139	WP_000187812.1	anaerobic ribonucleoside-triphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15195.55 Da
• Isoelectric Point: 8.1381

>T156773 WP_079793518.1 NZ_CP053416:c2447878-2447462 [Salmonella bongori]
MSKTYMLDTCICSFIMREQPEAVLKRLEQTVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLATAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Nucleotide

• Length: 417 bp

>T156773 NZ_CP069070:3564593-3564937 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8878.90 Da
• Isoelectric Point: 4.6677

>AT156773 WP_001261294.1 NZ_CP053416:c2448105-2447875 [Salmonella bongori]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Nucleotide

• Length: 231 bp

>AT156773 NZ_CP069070:3564934-3565263 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3V4SIC2