Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4361412..4362034 Replicon chromosome
Accession NZ_CP053398
Organism Serratia plymuthica strain C-1

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag HL670_RS20205 Protein ID WP_006322256.1
Coordinates 4361831..4362034 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag HL670_RS20200 Protein ID WP_004949348.1
Coordinates 4361412..4361780 (+) Length 123 a.a.

Genomic Context

HL670_RS20170HL670_RS20175HL670_RS20195HL670_RS20200HL670_RS20205HL670_RS20220HL670_RS20180HL670_RS20185HL670_RS20190HL670_RS20210HL670_RS20215HL670_RS20225HL670_RS20230
Location: 4357454..4357708 (255 bp)
Type: Others
Protein ID: WP_004949355.1
Location: 4357721..4357861 (141 bp)
Type: Others
Protein ID: WP_004949353.1
Location: 4360899..4361252 (354 bp)
Type: Others
Protein ID: WP_004949349.1
Location: 4361412..4361780 (369 bp)
Type: Antitoxin
Protein ID: WP_004949348.1
Location: 4361831..4362034 (204 bp)
Type: Toxin
Protein ID: WP_006322256.1
Location: 4364571..4364945 (375 bp)
Type: Others
Protein ID: WP_062793130.1
Location: 4357976..4358854 (879 bp)
Type: Others
Protein ID: WP_006323980.1
Location: 4358880..4359737 (858 bp)
Type: Others
Protein ID: WP_004949351.1
Location: 4359734..4360447 (714 bp)
Type: Others
Protein ID: WP_171407126.1
Location: 4362274..4362809 (536 bp)
Type: Others
Protein ID: Protein_3973
Location: 4362870..4364291 (1422 bp)
Type: Others
Protein ID: WP_062793128.1
Location: 4364942..4365771 (830 bp)
Type: Others
Protein ID: Protein_3976
Location: 4365804..4366265 (462 bp)
Type: Others
Protein ID: WP_062793132.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HL670_RS201704357454..4357708+255WP_004949355.1type B 50S ribosomal protein L31-
HL670_RS201754357721..4357861+141WP_004949353.1type B 50S ribosomal protein L36-
HL670_RS201804357976..4358854-879WP_006323980.1metal ABC transporter substrate-binding protein-
HL670_RS201854358880..4359737-858WP_004949351.1metal ABC transporter permease-
HL670_RS201904359734..4360447-714WP_171407126.1ABC transporter ATP-binding protein-
HL670_RS201954360899..4361252+354WP_004949349.1hypothetical protein-
HL670_RS202004361412..4361780+369WP_004949348.1Hha toxicity modulator TomBAntitoxin
HL670_RS202054361831..4362034+204WP_006322256.1hemolysin expression modulator HhaToxin
HL670_RS202104362274..4362809-536Protein_3973cytochrome b/b6 domain-containing protein-
HL670_RS202154362870..4364291-1422WP_062793128.1N-acetylglucosamine-binding protein GbpA-
HL670_RS202204364571..4364945+375WP_062793130.1type II secretion system pilot lipoprotein GspS-
HL670_RS202254364942..4365771-830Protein_3976prepilin peptidase-
HL670_RS202304365804..4366265-462WP_062793132.1type II secretion system protein M-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--4361412..437772616314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T156771 WP_006322256.1 NZ_CP053398:4361831-4362034 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T156771 NZ_CP069070:3187229-3187492 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT156771 WP_004949348.1 NZ_CP053398:4361412-4361780 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT156771 NZ_CP069070:3186944-3187225 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B1KM53

Antitoxin

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Source
ID
Structure
AlphaFold DBS4YKH5

References