Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4361412..4362034 Replicon chromosome
Accession NZ_CP053398
Organism Serratia plymuthica strain C-1

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag HL670_RS20205 Protein ID WP_006322256.1
Coordinates 4361831..4362034 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag HL670_RS20200 Protein ID WP_004949348.1
Coordinates 4361412..4361780 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL670_RS20170 4357454..4357708 + 255 WP_004949355.1 type B 50S ribosomal protein L31 -
HL670_RS20175 4357721..4357861 + 141 WP_004949353.1 type B 50S ribosomal protein L36 -
HL670_RS20180 4357976..4358854 - 879 WP_006323980.1 metal ABC transporter substrate-binding protein -
HL670_RS20185 4358880..4359737 - 858 WP_004949351.1 metal ABC transporter permease -
HL670_RS20190 4359734..4360447 - 714 WP_171407126.1 ABC transporter ATP-binding protein -
HL670_RS20195 4360899..4361252 + 354 WP_004949349.1 hypothetical protein -
HL670_RS20200 4361412..4361780 + 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
HL670_RS20205 4361831..4362034 + 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
HL670_RS20210 4362274..4362809 - 536 Protein_3973 cytochrome b/b6 domain-containing protein -
HL670_RS20215 4362870..4364291 - 1422 WP_062793128.1 N-acetylglucosamine-binding protein GbpA -
HL670_RS20220 4364571..4364945 + 375 WP_062793130.1 type II secretion system pilot lipoprotein GspS -
HL670_RS20225 4364942..4365771 - 830 Protein_3976 prepilin peptidase -
HL670_RS20230 4365804..4366265 - 462 WP_062793132.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4361412..4377726 16314


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T156771 WP_006322256.1 NZ_CP053398:4361831-4362034 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T156771 NZ_CP069070:3187229-3187492 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT156771 WP_004949348.1 NZ_CP053398:4361412-4361780 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT156771 NZ_CP069070:3186944-3187225 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References