Detailed information of TA system TA156770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3864550..3865106
• Replicon: chromosome
• Accession: NZ_CP053398
• Organism: Serratia plymuthica strain C-1

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: HL670_RS17675
• Protein ID: WP_062791405.1
• Coordinates: 3864550..3864867 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: HL670_RS17680
• Protein ID: WP_062791404.1
• Coordinates: 3864870..3865106 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HL670_RS17655	3860323..3861478	-	1156	Protein_3477	YbfB/YjiJ family MFS transporter	-
HL670_RS17660	3861586..3862503	+	918	WP_004942342.1	LysR family transcriptional regulator	-
HL670_RS17665	3862532..3863659	+	1128	WP_004942340.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
HL670_RS17670	3863674..3864516	+	843	WP_004942338.1	S-formylglutathione hydrolase	-
HL670_RS17675	3864550..3864867	-	318	WP_062791405.1	CcdB family protein	Toxin
HL670_RS17680	3864870..3865106	-	237	WP_062791404.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HL670_RS17685	3865251..3866159	-	909	WP_171407105.1	glutathione ABC transporter permease GsiD	-
HL670_RS17690	3866169..3867089	-	921	WP_004942334.1	glutathione ABC transporter permease GsiC	-
HL670_RS17695	3867141..3868679	-	1539	WP_062791402.1	glutathione ABC transporter substrate-binding protein GsiB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11942.94 Da
• Isoelectric Point: 7.9860

>T156770 WP_062791405.1 NZ_CP053398:c3864867-3864550 [Serratia plymuthica]
MQFTVYANTGKSAVYPLLLDVTRDIIGQLNRRVMIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGIR

Nucleotide

• Length: 318 bp

>T156770 NZ_CP069070:c3146527-3146135 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9122.22 Da
• Isoelectric Point: 6.7189

>AT156770 WP_062791404.1 NZ_CP053398:c3865106-3864870 [Serratia plymuthica]
MPVKQRTTQSVTMAVERSLLSRAREAGINLSATLNTALDAELRQHEMRKWKEENREAIDALNRFHEEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT156770 NZ_CP069070:c3146739-3146524 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA