Detailed information of TA system TA156768

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 3609356..3610120
• Replicon: chromosome
• Accession: NZ_CP053398
• Organism: Serratia plymuthica strain C-1

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HL670_RS16560
• Protein ID: WP_062792896.1
• Coordinates: 3609752..3610120 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HL670_RS16555
• Protein ID: WP_062792895.1
• Coordinates: 3609356..3609691 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HL670_RS16515	3604817..3605545	+	729	WP_062792891.1	WYL domain-containing protein	-
HL670_RS16520	3605680..3605958	+	279	WP_086016611.1	hypothetical protein	-
HL670_RS16525	3605991..3606278	+	288	WP_062792919.1	hypothetical protein	-
HL670_RS16530	3606291..3606602	+	312	WP_062792892.1	hypothetical protein	-
HL670_RS16535	3606642..3607112	+	471	WP_079251004.1	hypothetical protein	-
HL670_RS16540	3607170..3607703	+	534	WP_062792893.1	DUF4234 domain-containing protein	-
HL670_RS16545	3607791..3608612	+	822	WP_062792894.1	DUF945 domain-containing protein	-
HL670_RS16550	3608865..3609344	+	480	WP_062792921.1	DNA repair protein RadC	-
HL670_RS16555	3609356..3609691	+	336	WP_062792895.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HL670_RS16560	3609752..3610120	+	369	WP_062792896.1	TA system toxin CbtA family protein	Toxin
HL670_RS16565	3610117..3610446	+	330	WP_062792897.1	hypothetical protein	-
HL670_RS16570	3610550..3611383	+	834	WP_062792898.1	DUF4942 domain-containing protein	-
HL670_RS16580	3611841..3612500	+	660	WP_004942825.1	FtsH protease modulator YccA	-
HL670_RS16585	3612612..3612941	+	330	WP_004942823.1	sulfurtransferase TusE	-
HL670_RS16590	3612945..3613223	-	279	WP_004942821.1	acylphosphatase	-
HL670_RS16595	3613315..3614505	+	1191	WP_004942819.1	23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI	-
HL670_RS16600	3614567..3614883	+	317	Protein_3266	heat shock protein HspQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3519664..3611383	91719

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13854.01 Da
• Isoelectric Point: 8.2684

>T156768 WP_062792896.1 NZ_CP053398:3609752-3610120 [Serratia plymuthica]
MKTSPVPPKREVYSCPSPVAIWRDLLTYLLAQHYGLTVNDTVFSDDTIIQEHIEAGISLADALNFIVEKFDLVRIDRRGF
SCREQSPFVTVIDILRARQACGLMSRRGYRAITQTILGDKRP

Nucleotide

• Length: 369 bp

>T156768 NZ_CP069070:c3118807-3118451 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12418.08 Da
• Isoelectric Point: 6.7414

>AT156768 WP_062792895.1 NZ_CP053398:3609356-3609691 [Serratia plymuthica]
MTSINTPAWGLKRNVTPQLGARLVQQGNHLHYLADRAGISGTFNEVQTRHLDDAFPQFINHLELMLLSGELNPRYQHCVT
LYCNGLTCEADSLGSHGYVYISVYPTQMPVT

Nucleotide

• Length: 336 bp

>AT156768 NZ_CP069070:c3119021-3118791 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA