Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2163714..2164339 Replicon chromosome
Accession NZ_CP053398
Organism Serratia plymuthica strain C-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HL670_RS09890 Protein ID WP_071990198.1
Coordinates 2164157..2164339 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HL670_RS09885 Protein ID WP_062792521.1
Coordinates 2163714..2164127 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL670_RS09855 2158943..2159665 + 723 WP_004945948.1 RNA polymerase sigma factor FliA -
HL670_RS09860 2159722..2160231 + 510 WP_004945946.1 flagella biosynthesis regulatory protein FliZ -
HL670_RS09865 2160357..2161349 + 993 WP_062792520.1 D-cysteine desulfhydrase -
HL670_RS09870 2161463..2162263 + 801 WP_006326095.1 cystine ABC transporter substrate-binding protein -
HL670_RS09875 2162263..2162925 + 663 WP_004945937.1 cystine ABC transporter permease -
HL670_RS09880 2162929..2163681 + 753 WP_004945934.1 L-cystine ABC transporter ATP-binding protein YecC -
HL670_RS09885 2163714..2164127 - 414 WP_062792521.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HL670_RS09890 2164157..2164339 - 183 WP_071990198.1 type II toxin-antitoxin system HicA family toxin Toxin
HL670_RS09895 2164506..2168477 - 3972 WP_062792522.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
HL670_RS09900 2168580..2168840 + 261 WP_171407068.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6962.21 Da        Isoelectric Point: 11.0293

>T156759 WP_071990198.1 NZ_CP053398:c2164339-2164157 [Serratia plymuthica]
VKSAEPIRLLEREDWVLERIKGSHPQFKHPRSRLVITVPHPRKDPKPGTLRQIMKDAGLC

Download         Length: 183 bp

>T156759 NZ_CP069070:2474369-2474665 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACTTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15168.95 Da        Isoelectric Point: 4.6961

>AT156759 WP_062792521.1 NZ_CP053398:c2164127-2163714 [Serratia plymuthica]
MFYPAYVHSDYDGSASGFFPDVPVCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENAALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKVD

Download         Length: 414 bp

>AT156759 NZ_CP069070:2474121-2474372 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References