Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 828575..829244 Replicon chromosome
Accession NZ_CP053398
Organism Serratia plymuthica strain C-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A318NST4
Locus tag HL670_RS03675 Protein ID WP_004952425.1
Coordinates 828822..829244 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S4YS10
Locus tag HL670_RS03670 Protein ID WP_004952428.1
Coordinates 828575..828841 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL670_RS03645 823701..825025 + 1325 Protein_718 MHS family MFS transporter -
HL670_RS03650 825073..825681 - 609 WP_004952444.1 HD domain-containing protein -
HL670_RS03655 825872..826549 + 678 WP_004952439.1 hemolysin III family protein -
HL670_RS03660 826713..827210 + 498 WP_062792659.1 DUF2165 domain-containing protein -
HL670_RS03665 827264..828250 - 987 WP_062792658.1 tRNA-modifying protein YgfZ -
HL670_RS03670 828575..828841 + 267 WP_004952428.1 FAD assembly factor SdhE Antitoxin
HL670_RS03675 828822..829244 + 423 WP_004952425.1 protein YgfX Toxin
HL670_RS03680 829244..829939 + 696 WP_062792657.1 two-component system response regulator CreB -
HL670_RS03685 829936..831354 + 1419 WP_062792656.1 two-component system sensor histidine kinase CreC -
HL670_RS03690 831439..832803 + 1365 WP_004952415.1 cell envelope integrity protein CreD -
HL670_RS03695 832841..833359 - 519 WP_004952413.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16445.41 Da        Isoelectric Point: 11.2266

>T156758 WP_004952425.1 NZ_CP053398:828822-829244 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRFGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Download         Length: 423 bp

>T156758 NZ_CP069070:2452513-2452932 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10446.90 Da        Isoelectric Point: 5.0843

>AT156758 WP_004952428.1 NZ_CP053398:828575-828841 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT156758 NZ_CP069070:2452244-2452504 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318NST4

Antitoxin

Source ID Structure
AlphaFold DB S4YS10

References