156757

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 191512..192083 Replicon chromosome
Accession NZ_CP053398
Organism Serratia plymuthica strain C-1

Toxin (Protein)


Gene name relE Uniprot ID A0A318NZU8
Locus tag HL670_RS00835 Protein ID WP_041417217.1
Coordinates 191512..191790 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID S4YTP6
Locus tag HL670_RS00840 Protein ID WP_004951261.1
Coordinates 191814..192083 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HL670_RS00815 187678..188016 - 339 WP_006328508.1 PTS lactose/cellobiose transporter subunit IIA -
HL670_RS00820 188373..188942 + 570 WP_006328507.1 peptidylprolyl isomerase A -
HL670_RS00825 189102..190786 + 1685 Protein_164 sensor histidine kinase -
HL670_RS00830 190786..191511 + 726 WP_004951264.1 two-component system response regulator BtsR -
HL670_RS00835 191512..191790 - 279 WP_041417217.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HL670_RS00840 191814..192083 - 270 WP_004951261.1 hypothetical protein Antitoxin
HL670_RS00845 192313..193839 + 1527 WP_037433749.1 DUF853 family protein -
HL670_RS00850 193945..194520 + 576 WP_006328493.1 aminodeoxychorismate synthase component II -
HL670_RS00855 194652..195869 + 1218 WP_004951256.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10230.84 Da        Isoelectric Point: 8.5141

>T156757 WP_041417217.1 NZ_CP053398:c191790-191512 [Serratia plymuthica]
VTLKWTEPAIADRMAIYDYLETKNPAAAIEIDSLISAAATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T156757 NZ_CP069070:2445046-2445606 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10364.70 Da        Isoelectric Point: 7.0169

>AT156757 WP_004951261.1 NZ_CP053398:c192083-191814 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLIR

Download         Length: 270 bp

>AT156757 NZ_CP069070:2444708-2445049 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAATGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A318NZU8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KXK3

References