Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3861864..3862478 Replicon chromosome
Accession NZ_CP053390
Organism Pseudomonas aeruginosa strain TL1285

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag HMJ40_RS18005 Protein ID WP_071534354.1
Coordinates 3861864..3862046 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag HMJ40_RS18010 Protein ID WP_012077229.1
Coordinates 3862074..3862478 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMJ40_RS17980 (HMJ40_17995) 3857505..3857900 + 396 WP_003094374.1 hypothetical protein -
HMJ40_RS17985 (HMJ40_18000) 3857893..3859269 + 1377 WP_023101553.1 class II fumarate hydratase FumC -
HMJ40_RS17990 (HMJ40_18005) 3859297..3859746 + 450 WP_003094369.1 hypothetical protein -
HMJ40_RS17995 (HMJ40_18010) 3859759..3860370 + 612 WP_003098862.1 superoxide dismutase -
HMJ40_RS18000 (HMJ40_18015) 3860389..3861321 + 933 WP_003120918.1 ZIP family metal transporter -
HMJ40_RS18005 (HMJ40_18020) 3861864..3862046 + 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
HMJ40_RS18010 (HMJ40_18025) 3862074..3862478 + 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HMJ40_RS18015 (HMJ40_18030) 3862521..3863492 - 972 WP_012077228.1 hypothetical protein -
HMJ40_RS18020 (HMJ40_18035) 3863477..3864175 - 699 WP_033896049.1 hypothetical protein -
HMJ40_RS18025 (HMJ40_18040) 3864175..3864714 - 540 WP_012074127.1 hypothetical protein -
HMJ40_RS18030 (HMJ40_18045) 3864711..3865631 - 921 WP_012074128.1 hypothetical protein -
HMJ40_RS18035 (HMJ40_18050) 3865628..3866338 - 711 WP_012074129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3861864..3899358 37494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T156749 WP_071534354.1 NZ_CP053390:3861864-3862046 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T156749 NZ_CP069070:c1801160-1800747 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT156749 WP_012077229.1 NZ_CP053390:3862074-3862478 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT156749 NZ_CP069070:c1800708-1800451 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References