Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2774768..2775391 Replicon chromosome
Accession NZ_CP053383
Organism Halomonas sulfidivorans strain MCCC 1A13718

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HNO53_RS12815 Protein ID WP_209472643.1
Coordinates 2774768..2774950 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HNO53_RS12820 Protein ID WP_209472645.1
Coordinates 2774987..2775391 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNO53_RS12800 (HNO53_12795) 2770352..2771776 - 1425 WP_209472639.1 amidase -
HNO53_RS12805 (HNO53_12800) 2772063..2772305 + 243 WP_209472641.1 hypothetical protein -
HNO53_RS12810 (HNO53_12805) 2772678..2774351 + 1674 WP_242597420.1 methyl-accepting chemotaxis protein -
HNO53_RS12815 (HNO53_12810) 2774768..2774950 + 183 WP_209472643.1 type II toxin-antitoxin system HicA family toxin Toxin
HNO53_RS12820 (HNO53_12815) 2774987..2775391 + 405 WP_209472645.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HNO53_RS21605 2776100..2776234 - 135 WP_275951344.1 hypothetical protein -
HNO53_RS12825 (HNO53_12820) 2776620..2778851 - 2232 WP_209472647.1 EAL domain-containing protein -
HNO53_RS12830 (HNO53_12825) 2779078..2779728 - 651 WP_209472649.1 hypothetical protein -
HNO53_RS12835 (HNO53_12830) 2779976..2780206 + 231 WP_209472651.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2772678..2827462 54784


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6822.97 Da        Isoelectric Point: 10.8173

>T156745 WP_209472643.1 NZ_CP053383:2774768-2774950 [Halomonas sulfidivorans]
VKSRDLIRELEADGWYLDRVKGSHHIFKHPTKLSSVPVPHPKKDLPNGTVNSIRKLAVLK

Download         Length: 183 bp

>T156745 NZ_CP069070:1689589-1689906 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14837.82 Da        Isoelectric Point: 4.5413

>AT156745 WP_209472645.1 NZ_CP053383:2774987-2775391 [Halomonas sulfidivorans]
MQYPIAIEWGDEKTATGIVFPDIPGAITAGDTIEQAYEMAVEVAHIQLEELANAGQPIPKPRSIAEHRDNPEFDGWGWGL
VEIDLTPYLGKAEKVNVTLPGRLVKQIDDYVTLHGIKSRSAFLTRAAMHELERS

Download         Length: 405 bp

>AT156745 NZ_CP069070:1689290-1689592 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References