Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 221372..222004 Replicon chromosome
Accession NZ_CP053383
Organism Halomonas sulfidivorans strain MCCC 1A13718

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HNO53_RS01045 Protein ID WP_209475496.1
Coordinates 221372..221554 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HNO53_RS01050 Protein ID WP_209475498.1
Coordinates 221591..222004 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNO53_RS01020 (HNO53_01020) 216774..217283 + 510 WP_209475487.1 Hsp20/alpha crystallin family protein -
HNO53_RS01025 (HNO53_01025) 217333..218103 - 771 WP_209475489.1 fumarate/nitrate reduction transcriptional regulator Fnr -
HNO53_RS01030 (HNO53_01030) 219345..219827 + 483 WP_209475491.1 hypothetical protein -
HNO53_RS01035 (HNO53_01035) 219940..220551 + 612 WP_209475493.1 hypothetical protein -
HNO53_RS01040 (HNO53_01040) 220705..221154 + 450 WP_209475494.1 hypothetical protein -
HNO53_RS01045 (HNO53_01045) 221372..221554 + 183 WP_209475496.1 type II toxin-antitoxin system HicA family toxin Toxin
HNO53_RS01050 (HNO53_01050) 221591..222004 + 414 WP_209475498.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HNO53_RS01055 (HNO53_01055) 222086..223594 - 1509 WP_209475500.1 MFS transporter -
HNO53_RS01060 (HNO53_01060) 223650..224108 - 459 WP_167115854.1 universal stress protein -
HNO53_RS01065 (HNO53_01065) 224178..225809 - 1632 WP_209475502.1 MFS transporter -
HNO53_RS01070 (HNO53_01070) 226095..226763 - 669 WP_209475503.1 two-component system response regulator NarL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6803.93 Da        Isoelectric Point: 10.9041

>T156743 WP_209475496.1 NZ_CP053383:221372-221554 [Halomonas sulfidivorans]
VKSADLIKELEADGWTLDRVKGSHHHFRHPYKPGTITVPHPKKDLKRGLIQGIRKQAGLK

Download         Length: 183 bp

>T156743 NZ_CP069070:1542525-1543346 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15004.82 Da        Isoelectric Point: 4.9447

>AT156743 WP_209475498.1 NZ_CP053383:221591-222004 [Halomonas sulfidivorans]
MHYPIAIEVGDEQHAYGVVVPDLPGCFSAGDTFDEAIANAREAIEGHLESLSEHGDPIPTATAIQQHLENPDFAGWIWAA
VEIDMAPYLGKSHKINVTLPDLLIKRIDSTVAKHGDYKSRSGFLARAALHELERHAQ

Download         Length: 414 bp

>AT156743 NZ_CP069070:1543339-1543575 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References