Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 2985540..2986096 Replicon chromosome
Accession NZ_CP053382
Organism Halomonas sp. MCCC 1A13316

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HNO52_RS13795 Protein ID WP_197565842.1
Coordinates 2985785..2986096 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HNO52_RS13790 Protein ID WP_197565841.1
Coordinates 2985540..2985797 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNO52_RS13765 2980859..2981419 - 561 WP_197565838.1 hypothetical protein -
HNO52_RS13770 2981556..2982323 + 768 WP_197565839.1 glycerophosphoryl diester phosphodiesterase -
HNO52_RS13775 2982409..2982882 + 474 Protein_2703 CinA family protein -
HNO52_RS13780 2982952..2983749 + 798 WP_197569235.1 ammonia-dependent NAD(+) synthetase -
HNO52_RS13785 2984008..2985459 - 1452 WP_197565840.1 cobyric acid synthase -
HNO52_RS13790 2985540..2985797 + 258 WP_197565841.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HNO52_RS13795 2985785..2986096 + 312 WP_197565842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HNO52_RS13800 2986106..2986642 - 537 Protein_2708 nitroreductase family protein -
HNO52_RS13805 2986639..2987250 - 612 WP_197565843.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
HNO52_RS13810 2987263..2988585 - 1323 WP_197565844.1 cobyrinate a,c-diamide synthase -
HNO52_RS13815 2988587..2989354 - 768 WP_197565845.1 ABC transporter ATP-binding protein -
HNO52_RS13820 2989354..2990361 - 1008 WP_197565846.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11579.23 Da        Isoelectric Point: 4.5776

>T156741 WP_197565842.1 NZ_CP053382:2985785-2986096 [Halomonas sp. MCCC 1A13316]
MAEVIWAEPALTDLDAIAEHIALDNPAAASHLVEAVLDATERLQAFPQSGRIPTELPESVYREVLVPPCRVFYRASEEGV
LILHVMREERQLRAYLLEASRSR

Download         Length: 312 bp

>T156741 NZ_CP069070:1385924-1386355 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9954.51 Da        Isoelectric Point: 9.5342

>AT156741 WP_197565841.1 NZ_CP053382:2985540-2985797 [Halomonas sp. MCCC 1A13316]
MKVELVTNLKRQATNILAELHGSKEPVLITEHGKPSAYLVDVEDYEFMQRRLALLEGLSRGERAILEGRTYRQDEAKEKM
RKWLR

Download         Length: 258 bp

>AT156741 NZ_CP069070:1385667-1385927 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References