Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 2498941..2499513 Replicon chromosome
Accession NZ_CP053382
Organism Halomonas sp. MCCC 1A13316

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HNO52_RS11615 Protein ID WP_197569201.1
Coordinates 2498941..2499240 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HNO52_RS11620 Protein ID WP_197565473.1
Coordinates 2499289..2499513 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNO52_RS11600 2495246..2496568 - 1323 WP_197565471.1 UDP-glucose/GDP-mannose dehydrogenase family protein -
HNO52_RS11605 2496601..2497407 - 807 WP_197565472.1 lipopolysaccharide biosynthesis protein -
HNO52_RS11610 2497470..2498891 - 1422 WP_197569200.1 MBL fold metallo-hydrolase -
HNO52_RS11615 2498941..2499240 - 300 WP_197569201.1 DUF5615 family PIN-like protein Toxin
HNO52_RS11620 2499289..2499513 - 225 WP_197565473.1 DUF433 domain-containing protein Antitoxin
HNO52_RS11625 2499543..2500550 - 1008 WP_197565474.1 NAD-dependent epimerase -
HNO52_RS11630 2501061..2501561 - 501 WP_197565475.1 hypothetical protein -
HNO52_RS11635 2501569..2501838 - 270 WP_197569202.1 hypothetical protein -
HNO52_RS11640 2502205..2503026 + 822 WP_197569203.1 AraC family transcriptional regulator -
HNO52_RS11645 2503122..2503502 - 381 WP_197565476.1 DNA binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - fcl / gmd 2369787..2617550 247763


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(7-61)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11108.68 Da        Isoelectric Point: 4.8951

>T156740 WP_197569201.1 NZ_CP053382:c2499240-2498941 [Halomonas sp. MCCC 1A13316]
MKNCGVEEYSVRFLGYRDATDEALFAAARQANAIVLTKDRDFPELLDRHGPPPKIIWLTMGNTTNARMREVLGRLLPAAL
SLLERGESLVEFSEKGEET

Download         Length: 300 bp

>T156740 NZ_CP069070:1241001-1241375 [Mycobacterium tuberculosis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8387.72 Da        Isoelectric Point: 4.6683

>AT156740 WP_197565473.1 NZ_CP053382:c2499513-2499289 [Halomonas sp. MCCC 1A13316]
MRNLQSRITINPEQCGGRPCIRGMRIRVVDVLDLLAQGLTTEQILEEMPDLEQDDIYAVLQFAARRLDHPVLAA

Download         Length: 225 bp

>AT156740 NZ_CP069070:1240807-1241004 [Mycobacterium tuberculosis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References