Detailed information of TA system TA156738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 62633..63168
• Replicon: plasmid p2
• Accession: NZ_CP053380
• Organism: Serratia marcescens strain FY

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D5X8
• Locus tag: HMJ22_RS24800
• Protein ID: WP_004929861.1
• Coordinates: 62633..62920 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2LES3
• Locus tag: HMJ22_RS24805
• Protein ID: WP_038883487.1
• Coordinates: 62917..63168 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMJ22_RS24765	58402..58788	-	387	WP_171455199.1	relaxosome protein TraM	-
HMJ22_RS24770	59207..59677	+	471	WP_171455200.1	transglycosylase SLT domain-containing protein	-
HMJ22_RS24775	59962..60258	-	297	WP_171455201.1	hypothetical protein	-
HMJ22_RS24780	60360..61187	-	828	WP_171455202.1	DUF932 domain-containing protein	-
HMJ22_RS24785	61244..61615	-	372	WP_171455203.1	dehydrogenase	-
HMJ22_RS24790	62152..62382	-	231	WP_171455157.1	hypothetical protein	-
HMJ22_RS24795	62339..62566	-	228	WP_171455204.1	hypothetical protein	-
HMJ22_RS24800	62633..62920	-	288	WP_004929861.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMJ22_RS24805	62917..63168	-	252	WP_038883487.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HMJ22_RS24810	63620..64345	-	726	WP_171455205.1	plasmid SOS inhibition protein A	-
HMJ22_RS24815	64342..64782	-	441	WP_142076348.1	conjugation system SOS inhibitor PsiB	-
HMJ22_RS24820	64823..66901	-	2079	WP_171455206.1	ParB N-terminal domain-containing protein	-
HMJ22_RS24825	66987..67280	-	294	WP_171455231.1	ribulokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..87789	87789

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10875.93 Da
• Isoelectric Point: 10.2278

>T156738 WP_004929861.1 NZ_CP053380:c62920-62633 [Serratia marcescens]
MTYTVKFRESALKEWGKLDKALQQQFAKKLKKCCENPHIPSAKLRGMPGCYKIKLRASGFRLVYEVIDDCLIIAVVAVGK
RERGDVYQLASERLK

Nucleotide

• Length: 288 bp

>T156738 NZ_CP069070:1169107-1169988 [Mycobacterium tuberculosis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCTATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9182.46 Da
• Isoelectric Point: 4.0338

>AT156738 WP_038883487.1 NZ_CP053380:c63168-62917 [Serratia marcescens]
MPNIILSDTSASISELKKNPMETVGAGAGFPVAILNRNKPEFYCVPAALYEQMLDALDDQELVRLVNERRSEALVDIDLD
QFA

Nucleotide

• Length: 252 bp

>AT156738 NZ_CP069070:1168487-1169110 [Mycobacterium tuberculosis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D5X8