Detailed information of TA system TA156736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4711036..4711772
• Replicon: chromosome
• Accession: NZ_CP053378
• Organism: Serratia marcescens strain FY

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HMJ22_RS22290
• Protein ID: WP_171454883.1
• Coordinates: 4711293..4711772 (+)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5C7DAD3
• Locus tag: HMJ22_RS22285
• Protein ID: WP_015379309.1
• Coordinates: 4711036..4711296 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMJ22_RS22265	4707106..4707786	+	681	WP_171454882.1	GMP/IMP nucleotidase	-
HMJ22_RS22270	4707783..4708190	+	408	WP_015379306.1	ribosome-associated heat shock protein Hsp15	-
HMJ22_RS22275	4708216..4709094	+	879	WP_015379307.1	Hsp33 family molecular chaperone HslO	-
HMJ22_RS22280	4709289..4710908	+	1620	WP_015379308.1	phosphoenolpyruvate carboxykinase (ATP)	-
HMJ22_RS22285	4711036..4711296	+	261	WP_015379309.1	plasmid stability-like protein	Antitoxin
HMJ22_RS22290	4711293..4711772	+	480	WP_171454883.1	PIN domain-containing protein	Toxin
HMJ22_RS22295	4711805..4713175	-	1371	WP_031300055.1	two-component system sensor histidine kinase EnvZ	-
HMJ22_RS22300	4713172..4713891	-	720	WP_004709363.1	two-component system response regulator OmpR	-
HMJ22_RS22305	4714147..4714452	-	306	WP_004930739.1	chaperone-modulator protein CbpM	-
HMJ22_RS22310	4714458..4715420	-	963	WP_015379312.1	curved DNA-binding protein	-
HMJ22_RS22315	4715650..4716123	+	474	WP_004930745.1	transcription elongation factor GreB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17970.58 Da
• Isoelectric Point: 5.9070

>T156736 WP_171454883.1 NZ_CP053378:4711293-4711772 [Serratia marcescens]
MIVLDTNVVSELLRPAPHYNVLRWLDEQDTYRFYLSAIVVAELYTGIACMPHGKKQLELQTNLGDMLQEEFSDRILPFDV
GCAMQHAELMGANRRRGIGASMPDTQIAATCLHYGAALATRNTKDFLHCGIELIDPWQAPTGRRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T156736 NZ_CP069070:844302-844730 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9907.29 Da
• Isoelectric Point: 5.1898

>AT156736 WP_015379309.1 NZ_CP053378:4711036-4711296 [Serratia marcescens]
MATITVRNLDDEIKELLRISAAKNGHSMEEEARMILKQALVKKPPRYGLGTRMHQYFAEFGGVELEIPPRDEAPHRIVNF
DEDDEK

Nucleotide

• Length: 261 bp

>AT156736 NZ_CP069070:844021-844278 [Mycobacterium tuberculosis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DAD3