Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4126839..4127508 Replicon chromosome
Accession NZ_CP053378
Organism Serratia marcescens strain FY

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HMJ22_RS19510 Protein ID WP_004931681.1
Coordinates 4126839..4127261 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag HMJ22_RS19515 Protein ID WP_004931679.1
Coordinates 4127242..4127508 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMJ22_RS19490 4122768..4124501 - 1734 WP_171454693.1 single-stranded-DNA-specific exonuclease RecJ -
HMJ22_RS19495 4124508..4125224 - 717 WP_004931688.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HMJ22_RS19500 4125251..4126150 - 900 WP_004931685.1 site-specific tyrosine recombinase XerD -
HMJ22_RS19505 4126257..4126775 + 519 WP_004931683.1 flavodoxin FldB -
HMJ22_RS19510 4126839..4127261 - 423 WP_004931681.1 protein YgfX Toxin
HMJ22_RS19515 4127242..4127508 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
HMJ22_RS19520 4127829..4128821 + 993 WP_171454694.1 tRNA-modifying protein YgfZ -
HMJ22_RS19525 4128860..4129357 - 498 WP_044030541.1 DUF2165 domain-containing protein -
HMJ22_RS19530 4129508..4130182 - 675 WP_021505704.1 hemolysin III family protein -
HMJ22_RS19535 4130366..4130974 + 609 WP_033632167.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16487.59 Da        Isoelectric Point: 11.0198

>T156735 WP_004931681.1 NZ_CP053378:c4127261-4126839 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEQG

Download         Length: 423 bp

>T156735 NZ_CP069070:c758799-758362 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT156735 WP_004931679.1 NZ_CP053378:c4127508-4127242 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT156735 NZ_CP069070:c759050-758796 [Mycobacterium tuberculosis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References