Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3006381..3007012 Replicon chromosome
Accession NZ_CP053378
Organism Serratia marcescens strain FY

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HMJ22_RS14200 Protein ID WP_171454254.1
Coordinates 3006381..3006779 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HMJ22_RS14205 Protein ID WP_019452964.1
Coordinates 3006779..3007012 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMJ22_RS14175 3001953..3002327 + 375 WP_171454252.1 type II toxin-antitoxin system RelE/ParE family toxin -
HMJ22_RS14180 3002320..3002622 + 303 WP_015378258.1 DNA-binding transcriptional regulator -
HMJ22_RS14185 3002625..3003029 - 405 WP_171454253.1 flagellar protein FlhE -
HMJ22_RS14190 3003029..3005107 - 2079 WP_033643531.1 flagellar biosynthesis protein FlhA -
HMJ22_RS14195 3005100..3006251 - 1152 WP_047730459.1 flagellar type III secretion system protein FlhB -
HMJ22_RS14200 3006381..3006779 - 399 WP_171454254.1 tRNA(fMet)-specific endonuclease VapC Toxin
HMJ22_RS14205 3006779..3007012 - 234 WP_019452964.1 antitoxin Antitoxin
HMJ22_RS14210 3007138..3007782 - 645 WP_171454255.1 protein phosphatase CheZ -
HMJ22_RS14215 3007793..3008182 - 390 WP_004934862.1 chemotaxis response regulator CheY -
HMJ22_RS14220 3008285..3009334 - 1050 WP_015378262.1 chemotaxis response regulator protein-glutamate methylesterase -
HMJ22_RS14225 3009334..3010206 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
HMJ22_RS14230 3010235..3011860 - 1626 WP_004934871.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14868.00 Da        Isoelectric Point: 7.4001

>T156732 WP_171454254.1 NZ_CP053378:c3006779-3006381 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSVTYGELVHGVEKSSRPAVNARVVEDFVSRLDILDYGAKAASHY
GNIRAALERQGTPIGVDDLQIAGHARSEGLILVTNNRREFERVDGLRLENWL

Download         Length: 399 bp

>T156732 NZ_CP069070:c756394-756011 [Mycobacterium tuberculosis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7954

>AT156732 WP_019452964.1 NZ_CP053378:c3007012-3006779 [Serratia marcescens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPVENTWDSFFCAENEVSDDFLNERAGQHQREREEF

Download         Length: 234 bp

>AT156732 NZ_CP069070:c756644-756489 [Mycobacterium tuberculosis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCACCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References