Detailed information of TA system TA156723

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1524025..1524572
• Replicon: chromosome
• Accession: NZ_CP053378
• Organism: Serratia marcescens strain FY

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: HMJ22_RS07220
• Protein ID: WP_171453643.1
• Coordinates: 1524264..1524572 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A0G3SUU9
• Locus tag: HMJ22_RS07215
• Protein ID: WP_033633717.1
• Coordinates: 1524025..1524261 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMJ22_RS07200	1520511..1522046	+	1536	WP_171453642.1	glutathione ABC transporter substrate-binding protein GsiB	-
HMJ22_RS07205	1522099..1523019	+	921	WP_049241281.1	glutathione ABC transporter permease GsiC	-
HMJ22_RS07210	1523029..1523937	+	909	WP_169540348.1	glutathione ABC transporter permease GsiD	-
HMJ22_RS07215	1524025..1524261	+	237	WP_033633717.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
HMJ22_RS07220	1524264..1524572	+	309	WP_171453643.1	CcdB family protein	Toxin
HMJ22_RS07225	1524609..1525451	-	843	WP_048322602.1	S-formylglutathione hydrolase	-
HMJ22_RS07230	1525466..1526590	-	1125	WP_048322603.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
HMJ22_RS07235	1526620..1527540	-	921	WP_171453644.1	LysR family transcriptional regulator	-
HMJ22_RS07240	1527646..1528803	+	1158	WP_031299819.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (8-78)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11478.24 Da
• Isoelectric Point: 5.0196

>T156723 WP_171453643.1 NZ_CP053378:1524264-1524572 [Serratia marcescens]
MQFTVYDNTYPTSAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNANEHRNQIKAAIDFLIDGF

Nucleotide

• Length: 309 bp

>T156723 NZ_CP069070:c447360-446767 [Mycobacterium tuberculosis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8994.07 Da
• Isoelectric Point: 5.0807

>AT156723 WP_033633717.1 NZ_CP053378:1524025-1524261 [Serratia marcescens]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Nucleotide

• Length: 237 bp

>AT156723 NZ_CP069070:c447778-447389 [Mycobacterium tuberculosis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0G3SUU9