Detailed information of TA system TA156717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 20542..21050
• Replicon: plasmid pG32-51
• Accession: NZ_CP053373
• Organism: Proteus terrae subsp. cibarius strain G32

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HND96_RS19605
• Protein ID: WP_050878415.1
• Coordinates: 20542..20817 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HND96_RS19610
• Protein ID: WP_050878414.1
• Coordinates: 20826..21050 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HND96_RS19575	15994..16302	-	309	WP_050878424.1	hypothetical protein	-
HND96_RS19580	16495..16788	-	294	WP_050878422.1	sigma-70 family RNA polymerase sigma factor	-
HND96_RS19585	16896..17231	-	336	WP_050878420.1	hypothetical protein	-
HND96_RS19590	17328..18155	-	828	WP_050878418.1	GIY-YIG nuclease family protein	-
HND96_RS19595	18165..18995	-	831	WP_050878417.1	replication initiation protein	-
HND96_RS19600	19665..19838	+	174	WP_154393749.1	hypothetical protein	-
HND96_RS19605	20542..20817	-	276	WP_050878415.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HND96_RS19610	20826..21050	-	225	WP_050878414.1	hypothetical protein	Antitoxin
HND96_RS19615	21262..22485	+	1224	WP_159364217.1	DUF3560 domain-containing protein	-
HND96_RS19620	22583..22963	+	381	WP_050878412.1	hypothetical protein	-
HND96_RS19625	23527..23862	+	336	WP_050878410.1	hypothetical protein	-
HND96_RS19630	23940..24182	+	243	WP_156734530.1	hypothetical protein	-
HND96_RS19635	24219..24998	+	780	WP_050878406.1	hypothetical protein	-
HND96_RS19640	25052..25336	+	285	WP_050878404.1	hypothetical protein	-
HND96_RS19645	25340..25549	+	210	WP_050878402.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	cfr	-	1..51686	51686

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (5-70)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11101.99 Da
• Isoelectric Point: 10.1375

>T156717 WP_050878415.1 NZ_CP053373:c20817-20542 [Proteus terrae subsp. cibarius]
MDHYRIEYTKRFQKEIKKIDKYHQKIIQNYIEKHIDNSINPRLIGKILKGDKAEFIRYRIGDYRLIATIEDDKLLILALS
IGHRKDIYKHF

Nucleotide

• Length: 276 bp

>T156717 NZ_CP069069:c3815769-3815377 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8490.46 Da
• Isoelectric Point: 4.2696

>AT156717 WP_050878414.1 NZ_CP053373:c21050-20826 [Proteus terrae subsp. cibarius]
MRKNSTKAIRLNDDELTLFESYANAKGLTFSELCKSAVIEKIEDEIDLKLAEESYNEYLNDNETLSHKALFDSL

Nucleotide

• Length: 225 bp

>AT156717 NZ_CP069069:c3816044-3815769 [Mycobacterium tuberculosis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA