Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3712394..3713093 Replicon chromosome
Accession NZ_CP053371
Organism Proteus terrae subsp. cibarius strain G32

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HND96_RS17200 Protein ID WP_159364182.1
Coordinates 3712394..3712780 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HND96_RS17205 Protein ID WP_075671318.1
Coordinates 3712773..3713093 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HND96_RS17185 3708432..3709016 - 585 WP_075671324.1 DNA-3-methyladenine glycosylase I -
HND96_RS17190 3709255..3710160 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
HND96_RS17195 3710170..3712242 + 2073 WP_075671322.1 glycine--tRNA ligase subunit beta -
HND96_RS17200 3712394..3712780 + 387 WP_159364182.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HND96_RS17205 3712773..3713093 + 321 WP_075671318.1 helix-turn-helix domain-containing protein Antitoxin
HND96_RS17210 3713160..3713480 - 321 WP_075671316.1 hypothetical protein -
HND96_RS17215 3713586..3714872 - 1287 WP_075671314.1 DUF3748 domain-containing protein -
HND96_RS17220 3715009..3715626 + 618 WP_006534609.1 trimeric intracellular cation channel family protein -
HND96_RS17225 3715932..3716555 + 624 WP_006534608.1 guanylate kinase -
HND96_RS17230 3716610..3716885 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-96)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14388.78 Da        Isoelectric Point: 10.0463

>T156713 WP_159364182.1 NZ_CP053371:3712394-3712780 [Proteus terrae subsp. cibarius]
MVIYKTKMFKNSFKKMPINDATLIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Download         Length: 387 bp

>T156713 NZ_CP069069:3195825-3196268 [Mycobacterium tuberculosis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12068.99 Da        Isoelectric Point: 10.0482

>AT156713 WP_075671318.1 NZ_CP053371:3712773-3713093 [Proteus terrae subsp. cibarius]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Download         Length: 321 bp

>AT156713 NZ_CP069069:3195581-3195838 [Mycobacterium tuberculosis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References