156700

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2307913..2308570 Replicon chromosome
Accession NZ_CP053364
Organism Klebsiella pneumoniae strain BA2275

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag C5707_RS11445 Protein ID WP_002916310.1
Coordinates 2307913..2308323 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag C5707_RS11450 Protein ID WP_002916312.1
Coordinates 2308304..2308570 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5707_RS11425 2303913..2305646 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
C5707_RS11430 2305652..2306365 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C5707_RS11435 2306388..2307284 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
C5707_RS11440 2307385..2307906 + 522 WP_002916308.1 flavodoxin FldB -
C5707_RS11445 2307913..2308323 - 411 WP_002916310.1 protein YgfX Toxin
C5707_RS11450 2308304..2308570 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
C5707_RS11455 2308816..2309799 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
C5707_RS11460 2309950..2310609 - 660 WP_002916317.1 hemolysin III family protein -
C5707_RS11465 2310773..2311084 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
C5707_RS11470 2311134..2311862 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
C5707_RS11475 2311981..2313414 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T156700 WP_002916310.1 NZ_CP053364:c2308323-2307913 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T156700 NZ_CP069069:2820364-2820789 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT156700 WP_002916312.1 NZ_CP053364:c2308570-2308304 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT156700 NZ_CP069069:2820137-2820358 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATAAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References