Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 787508..788165 Replicon chromosome
Accession NZ_CP053358
Organism Klebsiella pneumoniae strain EGKP6

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HMI21_RS03915 Protein ID WP_002916310.1
Coordinates 787755..788165 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HMI21_RS03910 Protein ID WP_002916312.1
Coordinates 787508..787774 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMI21_RS03885 (782664) 782664..784097 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HMI21_RS03890 (784216) 784216..784944 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HMI21_RS03895 (784994) 784994..785305 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HMI21_RS03900 (785469) 785469..786128 + 660 WP_002916317.1 hemolysin III family protein -
HMI21_RS03905 (786279) 786279..787262 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
HMI21_RS03910 (787508) 787508..787774 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HMI21_RS03915 (787755) 787755..788165 + 411 WP_002916310.1 protein YgfX Toxin
HMI21_RS03920 (788172) 788172..788693 - 522 WP_004144730.1 flavodoxin FldB -
HMI21_RS03925 (788794) 788794..789690 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HMI21_RS03930 (789713) 789713..790426 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HMI21_RS03935 (790432) 790432..792165 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T156672 WP_002916310.1 NZ_CP053358:787755-788165 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T156672 NZ_CP069069:719596-720003 [Mycobacterium tuberculosis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT156672 WP_002916312.1 NZ_CP053358:787508-787774 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT156672 NZ_CP069069:719339-719599 [Mycobacterium tuberculosis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References