Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1431704..1432181 Replicon chromosome
Accession NZ_CP053356
Organism Staphylococcus aureus strain 14507

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag HA034_RS07555 Protein ID WP_000052076.1
Coordinates 1431993..1432181 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HA034_RS07550 Protein ID WP_001059690.1
Coordinates 1431704..1431964 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HA034_RS07515 1427097..1427813 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
HA034_RS07520 1427961..1428383 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
HA034_RS07525 1428782..1429276 + 495 WP_000569883.1 GNAT family N-acetyltransferase -
HA034_RS07530 1429431..1430048 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
HA034_RS07535 1430121..1430702 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
HA034_RS07540 1430927..1431163 + 237 WP_000349581.1 hypothetical protein -
HA034_RS07545 1431160..1431363 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HA034_RS07550 1431704..1431964 + 261 WP_001059690.1 hypothetical protein Antitoxin
HA034_RS07555 1431993..1432181 + 189 WP_000052076.1 hypothetical protein Toxin
HA034_RS07560 1432369..1432938 + 570 WP_001106658.1 hypothetical protein -
HA034_RS07565 1433026..1433295 + 270 WP_001004398.1 hypothetical protein -
HA034_RS07570 1433372..1433590 + 219 WP_000005886.1 hypothetical protein -
HA034_RS07575 1434082..1434282 - 201 WP_001059082.1 cold-shock protein -
HA034_RS07580 1434639..1435325 - 687 WP_000141557.1 thermonuclease family protein -
HA034_RS07585 1435666..1436187 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-128)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T156665 WP_000052076.1 NZ_CP053356:1431993-1432181 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T156665 NZ_CP069069:c642177-641764 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT156665 WP_001059690.1 NZ_CP053356:1431704-1431964 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT156665 NZ_CP069069:c642440-642174 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References