Detailed information of TA system TA156655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 102428..102957
• Replicon: chromosome
• Accession: NZ_CP053356
• Organism: Staphylococcus aureus strain 14507

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HA034_RS00640
• Protein ID: WP_000621175.1
• Coordinates: 102595..102957 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: HA034_RS00635
• Protein ID: WP_000948331.1
• Coordinates: 102428..102598 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA034_RS00605	97465..98025	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
HA034_RS00610	98233..98712	+	480	WP_001287087.1	hypothetical protein	-
HA034_RS00615	98705..100288	+	1584	WP_001294626.1	PH domain-containing protein	-
HA034_RS00620	100275..100766	+	492	WP_001205912.1	PH domain-containing protein	-
HA034_RS00625	100770..101129	+	360	WP_000581197.1	holo-ACP synthase	-
HA034_RS00630	101195..102343	+	1149	WP_001281154.1	alanine racemase	-
HA034_RS00635	102428..102598	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HA034_RS00640	102595..102957	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HA034_RS00645	103307..104308	+	1002	WP_000390827.1	PP2C family protein-serine/threonine phosphatase	-
HA034_RS00650	104427..104753	+	327	WP_001052491.1	anti-sigma factor antagonist	-
HA034_RS00655	104755..105234	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
HA034_RS00660	105209..105979	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T156655 WP_000621175.1 NZ_CP053356:102595-102957 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T156655 NZ_CP069068:3559110-3559454 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT156655 WP_000948331.1 NZ_CP053356:102428-102598 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT156655 NZ_CP069068:3559451-3559780 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1