Detailed information of TA system TA156646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2631596..2632372
• Replicon: plasmid unnamed
• Accession: NZ_CP053353
• Organism: Staphylococcus aureus strain 16405

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: HA035_RS12925
• Protein ID: WP_000031108.1
• Coordinates: 2631596..2631748 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: HA035_RS12930
• Protein ID: WP_031806872.1
• Coordinates: 2631773..2632372 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HA035_RS12910	2627676..2628497	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
HA035_RS12915	2628960..2630345	-	1386	WP_000116224.1	class II fumarate hydratase	-
HA035_RS12920	2630541..2630936	-	396	WP_000901021.1	hypothetical protein	-
HA035_RS12925	2631596..2631748	-	153	WP_000031108.1	hypothetical protein	Toxin
HA035_RS12930	2631773..2632372	-	600	WP_031806872.1	glucosamine-6-phosphate isomerase	Antitoxin
HA035_RS12935	2632531..2633001	-	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
HA035_RS12940	2633006..2634133	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
HA035_RS12945	2634284..2635006	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
HA035_RS12950	2634999..2636456	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	mecA / blaZ / dfrG	hysA / sbi / hlgA / hlgC / hlgB / bpsC / fnbB / fnbA / aur / icaR / icaA / icaD / icaB / icaC / lip / adsA / adsA / spa / cap8A / cap8B / cap8C / cap8D / cap8D / cap8E / cap8E / cap8F / cap8G / cap8L / cap8M / cap8N / cap8O / cap8P / coa / esxA / esaA / essA / esaB / essB / essC / esxC / esxB / esaE / esxD / esaD / esaG4 / esaG1 / esaG7 / esaG3 / esaG3 / esaG4 / esaG9 / geh / clpC / tufA / sdrC / sdrD / sdrE / clpP / vWbp / sspC / sspB / sspA / isdB / isdA / isdC / isdD / isdE / isdF / srtB / isdG / hly/hla / acpXL / katA / ebp / gnd / lukD / hlgA / map / hlb / scn / sak / sea / hlb / groEL / hld	1..2868068	2868068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T156646 WP_000031108.1 NZ_CP053353:c2631748-2631596 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T156646 NZ_CP069068:2934484-2934924 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22333.43 Da
• Isoelectric Point: 5.1445

>AT156646 WP_031806872.1 NZ_CP053353:c2632372-2631773 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQASVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT156646 NZ_CP069068:2934210-2934497 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Structures

Toxin

• AlphaFold DB: X5E2E6