Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1542280..1542757 | Replicon | plasmid unnamed |
| Accession | NZ_CP053353 | ||
| Organism | Staphylococcus aureus strain 16405 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q2G005 |
| Locus tag | HA035_RS07565 | Protein ID | WP_000052078.1 |
| Coordinates | 1542280..1542468 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | HA035_RS07570 | Protein ID | WP_001059690.1 |
| Coordinates | 1542497..1542757 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HA035_RS07535 | 1538321..1538791 | + | 471 | WP_000824472.1 | hypothetical protein | - |
| HA035_RS07540 | 1539132..1539818 | + | 687 | WP_001548082.1 | thermonuclease family protein | - |
| HA035_RS07545 | 1540175..1540375 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| HA035_RS07550 | 1540871..1541089 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| HA035_RS07555 | 1541151..1541435 | - | 285 | WP_001004395.1 | hypothetical protein | - |
| HA035_RS07560 | 1541523..1542092 | - | 570 | WP_001106654.1 | hypothetical protein | - |
| HA035_RS07565 | 1542280..1542468 | - | 189 | WP_000052078.1 | hypothetical protein | Toxin |
| HA035_RS07570 | 1542497..1542757 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| HA035_RS07575 | 1543098..1543301 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| HA035_RS07580 | 1543298..1543534 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| HA035_RS07585 | 1543759..1544340 | + | 582 | WP_001140686.1 | phosphoglycerate mutase family protein | - |
| HA035_RS07590 | 1544413..1545030 | - | 618 | WP_000255561.1 | LysE/ArgO family amino acid transporter | - |
| HA035_RS07595 | 1545185..1545679 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| HA035_RS07600 | 1546078..1546500 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| HA035_RS07605 | 1546648..1547364 | + | 717 | WP_000150017.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mecA / blaZ / dfrG | hysA / sbi / hlgA / hlgC / hlgB / bpsC / fnbB / fnbA / aur / icaR / icaA / icaD / icaB / icaC / lip / adsA / adsA / spa / cap8A / cap8B / cap8C / cap8D / cap8D / cap8E / cap8E / cap8F / cap8G / cap8L / cap8M / cap8N / cap8O / cap8P / coa / esxA / esaA / essA / esaB / essB / essC / esxC / esxB / esaE / esxD / esaD / esaG4 / esaG1 / esaG7 / esaG3 / esaG3 / esaG4 / esaG9 / geh / clpC / tufA / sdrC / sdrD / sdrE / clpP / vWbp / sspC / sspB / sspA / isdB / isdA / isdC / isdD / isdE / isdF / srtB / isdG / hly/hla / acpXL / katA / ebp / gnd / lukD / hlgA / map / hlb / scn / sak / sea / hlb / groEL / hld | 1..2868068 | 2868068 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7172.84 Da Isoelectric Point: 9.9971
>T156643 WP_000052078.1 NZ_CP053353:c1542468-1542280 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T156643 NZ_CP069068:2872336-2872749 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT156643 WP_001059690.1 NZ_CP053353:c1542757-1542497 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT156643 NZ_CP069068:2872788-2873045 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGACTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGACTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D6HZ40 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |