Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsdAT/- |
| Location | 26647..27161 | Replicon | plasmid unnamed |
| Accession | NZ_CP053353 | ||
| Organism | Staphylococcus aureus strain 16405 | ||
Toxin (Protein)
| Gene name | TsdT | Uniprot ID | T1YA99 |
| Locus tag | HA035_RS00135 | Protein ID | WP_000581792.1 |
| Coordinates | 26647..26856 (-) | Length | 70 a.a. |
Antitoxin (Protein)
| Gene name | TsdA | Uniprot ID | W8UW13 |
| Locus tag | HA035_RS00140 | Protein ID | WP_000138932.1 |
| Coordinates | 26868..27161 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HA035_RS00115 | 22155..23513 | - | 1359 | WP_000611462.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| HA035_RS00120 | 23528..24598 | - | 1071 | WP_000159631.1 | D-alanine--D-alanine ligase | - |
| HA035_RS00125 | 24916..26118 | + | 1203 | WP_001109939.1 | rod shape-determining protein RodA | - |
| HA035_RS00130 | 26382..26519 | - | 138 | WP_000828354.1 | hypothetical protein | - |
| HA035_RS00135 | 26647..26856 | - | 210 | WP_000581792.1 | heavy-metal-associated domain-containing protein | Toxin |
| HA035_RS00140 | 26868..27161 | - | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
| HA035_RS00145 | 27327..28811 | + | 1485 | WP_000571549.1 | cardiolipin synthase | - |
| HA035_RS00150 | 28839..29486 | + | 648 | WP_001187629.1 | HD domain-containing protein | - |
| HA035_RS00155 | 30199..31071 | - | 873 | WP_000725802.1 | membrane protein insertase YidC | - |
| HA035_RS00160 | 31157..31798 | - | 642 | WP_000483153.1 | thiamine phosphate synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mecA / blaZ / dfrG | hysA / sbi / hlgA / hlgC / hlgB / bpsC / fnbB / fnbA / aur / icaR / icaA / icaD / icaB / icaC / lip / adsA / adsA / spa / cap8A / cap8B / cap8C / cap8D / cap8D / cap8E / cap8E / cap8F / cap8G / cap8L / cap8M / cap8N / cap8O / cap8P / coa / esxA / esaA / essA / esaB / essB / essC / esxC / esxB / esaE / esxD / esaD / esaG4 / esaG1 / esaG7 / esaG3 / esaG3 / esaG4 / esaG9 / geh / clpC / tufA / sdrC / sdrD / sdrE / clpP / vWbp / sspC / sspB / sspA / isdB / isdA / isdC / isdD / isdE / isdF / srtB / isdG / hly/hla / acpXL / katA / ebp / gnd / lukD / hlgA / map / hlb / scn / sak / sea / hlb / groEL / hld | 1..2868068 | 2868068 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7843.77 Da Isoelectric Point: 4.1008
>T156636 WP_000581792.1 NZ_CP053353:c26856-26647 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
Download Length: 210 bp
>T156636 NZ_CP069068:c2239645-2239301 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT156636 WP_000138932.1 NZ_CP053353:c27161-26868 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT156636 NZ_CP069068:c2239887-2239639 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|